Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2025; 13(26): 106999
Published online Sep 16, 2025. doi: 10.12998/wjcc.v13.i26.106999
Late menstruation with an ovarian sclerosing stromal tumor: A case report
Xu Han, Bo Zhang, Jing-Chun Gao
Xu Han, Jing-Chun Gao, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Bo Zhang, Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Author contributions: Han X wrote the manuscript; Gao JC made critical revisions to the manuscript for important intellectual content; Zhang B was responsible for image collection; all authors discussed the first draft of the paper and provided suggestions for revision, read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this anonymized report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Chun Gao, PhD, Professor, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Xigang District, Dalian 116000, Liaoning Province, China. jingchun_gao@hotmail.com
Received: March 14, 2025
Revised: April 29, 2025
Accepted: June 11, 2025
Published online: September 16, 2025
Processing time: 132 Days and 4.1 Hours
Abstract
BACKGROUND

Ovarian sclerosing stromal tumors (OSSTs) are found most commonly in females at 20-30 years of age. They can also occur at any point during pre-puberty, puberty, or menopause. Clinical manifestations of OSSTs include abdominal pain, an abdominal mass, menstrual abnormalities, and infertility. Infrequently, patients will experience androgen-related manifestations of masculinization, such as increased hair, acne, or a low voice. Diagnosis must be confirmed by immunohistochemical analysis of the tissue as clinical symptoms and imaging studies are unreliable.

CASE SUMMARY

A 14-year-old female presented with amenorrhea. After a thorough medical examination, endocrine and tumor markers analysis, and imaging, a pelvic mass was discovered. The patient also exhibited endocrine dysfunction but was not positive for any tumor markers. The patient underwent surgery to remove the ovarian tumor. Immunohistochemical analysis of the resected specimen indicated an OSST. During the postoperative follow-up, the patient had attained menarche.

CONCLUSION

This case’s clinical manifestation of endocrine dysfunction due to OSST provides new insights that will assist clinicians in the diagnosis and treatment of this common tumor.

Keywords: Ovarian sclerosing stromal tumor; Ovarian tumor; Ovarian sex cord stromal tumor; Menarche; Testosterone; Case report

Core Tip: Ovarian sclerosing stromal tumor (OSSTs) are found most commonly in females at 20-30 years of age. OSST is a rare tumor and is even rarer during puberty or menopause. We report a case of a 14-year-old female who had not yet reached menarche. After thorough examination at our clinic, a pelvic mass was discovered. The patient underwent surgery and reached menarche. Immunohistochemical analysis of the resected specimen provided definitive diagnosis of an OSST. This case highlights the importance of a thorough examination and pathological analysis to properly diagnose and treat patients with OSST.