Zhu W. Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder. World J Clin Cases 2025; 13(2): 98319 [DOI: 10.12998/wjcc.v13.i2.98319]
Corresponding Author of This Article
Wei Zhu, PhD, CEO, Postdoctoral Fellow, Researcher, Shanghai XiRong Information Science and Technology Co., Ltd, National Science and Technology Park, School of Life Sciences and Technology, Tongji University, No. 1239 Siping Road, Yangpu District, Shanghai 200092, China. zhuwei8247@aliyun.com
Research Domain of This Article
Pediatrics
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 16, 2025; 13(2): 98319 Published online Jan 16, 2025. doi: 10.12998/wjcc.v13.i2.98319
Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder
Wei Zhu
Wei Zhu, Shanghai XiRong Information Science and Technology Co., Ltd, National Science and Technology Park, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China
Author contributions: Zhu W designed the study, wrote the manuscript and prepared the Figures, as well as other associated work; the author read and approved the final version of the manuscript to be published.
Supported byNatural Science Foundation of Shanghai, No. 17ZR1431400; and National Key R and D Program of China, No. 2017YFA0103902.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Zhu, PhD, CEO, Postdoctoral Fellow, Researcher, Shanghai XiRong Information Science and Technology Co., Ltd, National Science and Technology Park, School of Life Sciences and Technology, Tongji University, No. 1239 Siping Road, Yangpu District, Shanghai 200092, China. zhuwei8247@aliyun.com
Received: June 24, 2024 Revised: September 25, 2024 Accepted: October 16, 2024 Published online: January 16, 2025 Processing time: 136 Days and 17.8 Hours
Abstract
Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 gene. Attention-deficit/hyperactivity disorder (ADHD) is considered a neurodevelopment and psychiatric disorder in childhood. Genetic characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and ADHD. Magnetic resonance imaging (MRI) has been used to assess medical images in Sotos syndrome and ADHD. The images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this editorial. In the future, genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.
Core Tip: Nuclear receptor binding SET domain protein 1 (NSD1) gene mutation has been shown to be involved in the process of Sotos syndrome but without a confirmed effect on patients with attention-deficit/hyperactivity disorder (ADHD). The case report by Yang et al showed a meaningful result to indicate that NSD1 gene mutation existed in a pediatric patient with Sotos syndrome and ADHD.
