Jiang J, Shi HT, Wu J, Sha SM, Cai SX, Liu X. Successful treatment of depressed esophageal squamous papilloma with interferon- alpha 2a: A case report. World J Clin Cases 2025; 13(19): 99311 [DOI: 10.12998/wjcc.v13.i19.99311]
Corresponding Author of This Article
Jiong Jiang, PhD, Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an 710004, Shaanxi Province, China. jjangus712@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 6, 2025; 13(19): 99311 Published online Jul 6, 2025. doi: 10.12998/wjcc.v13.i19.99311
Successful treatment of depressed esophageal squamous papilloma with interferon- alpha 2a: A case report
Jiong Jiang, Hai-Tao Shi, Jie Wu, Su-Mei Sha, Shang-Xuan Cai, Xin Liu
Jiong Jiang, Hai-Tao Shi, Su-Mei Sha, Shang-Xuan Cai, Xin Liu, Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China
Jie Wu, Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China
Co-corresponding authors: Jiong Jiang and Xin Liu.
Author contributions: Jiang J data analysis and writing; Shi HT literature search; Wu J histological and pathological analysis; Sha SM collation of clinical case data; Cai SX clinical data acquisition; Liu X visualization, writing-review & editing. All authors have read and approved the final manuscript. Jiang J, the first author of the paper, was the attending physician of the patient, responsible for the implementation and formulation of the diagnosis and treatment plan of the patient during hospitalization, and the operation of each gastroscopy review of the patient after treatment. She was also the author of the paper and the corresponding author of the paper. Liu X, the other corresponding author, was the superior doctor in charge of the patient during hospitalization. Professor, responsible for the formulation of treatment plan and efficacy supervision during the patient's hospitalization, as well as the formulation of follow-up plan, the two authors occupy the same important position in the whole treatment process of the patient, so they are co-corresponding authors.
Supported by Key Research & Development Program of Shaanxi Province, No. 2021SF-221.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiong Jiang, PhD, Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 Xiwu Road, Xi'an 710004, Shaanxi Province, China. jjangus712@163.com
Received: July 19, 2024 Revised: January 27, 2025 Accepted: February 26, 2025 Published online: July 6, 2025 Processing time: 242 Days and 21.4 Hours
Abstract
BACKGROUND
Esophageal squamous papilloma (ESP) is a rare benign tumor of the esophagus, typically characterized by an exophytic and warty appearance, with a diameter of less than 5 mm. Endoscopic resection is considered the most effective treatment for these tumors.
CASE SUMMARY
In this paper, we discussed the pathogenesis, clinical characteristics, and therapeutic options of ESP based on our experience with a case presenting a depressed appearance and treated with interferon-alpha 2a (IFNα2a) injection.
CONCLUSION
This paper reports the first successful clinical case of using the human IFNα2a for the treatment of ESP with a depressed endoscopic appearance. However, the efficacy of interferon treatment requires to validation in a large number of subsequent cases.
Core Tip: Esophageal squamous papilloma (ESP) is a rare benign epithelial tumor of the esophagus, typically presenting with an exophytic and warty appearance, often measuring less than 5 mm in diameter. Endoscopic resection is regarded as the most effective treatment for these tumors. However, the complete resection rate remains low. In this paper, we reported a case of ESP located in the lower esophagus that exhibited an unusual depressed endoscopic appearance with a diameter approaching 2 cm, which showed significant therapeutic outcomes by recombinant human interferon-alpha 2a. Nevertheless, further validation of the efficacy of interferon treatment is necessary through larger-scale studies involving subsequent cases.
