Lackovic MM, Joksimovic BD, Babovic JC, Isenovic ER, Gluvic ZM. Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism in juvenile patient. World J Clin Cases 2025; 13(17): 100439 [PMID: 40524772 DOI: 10.12998/wjcc.v13.i17.100439]
Corresponding Author of This Article
Zoran M Gluvic, MD, PhD, Associate Professor, Department of Endocrinology, University Clinical-Hospital Centre Zemun-Belgrade, Faculty of Medicine, University of Belgrade, Vukova 9, Belgrade 11080, Serbia. zorangluvic@yahoo.com
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Endocrinology & Metabolism
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Letter to the Editor
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Jun 16, 2025 (publication date) through Mar 10, 2026
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World Journal of Clinical Cases
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Lackovic MM, Joksimovic BD, Babovic JC, Isenovic ER, Gluvic ZM. Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism in juvenile patient. World J Clin Cases 2025; 13(17): 100439 [PMID: 40524772 DOI: 10.12998/wjcc.v13.i17.100439]
World J Clin Cases. Jun 16, 2025; 13(17): 100439 Published online Jun 16, 2025. doi: 10.12998/wjcc.v13.i17.100439
Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism in juvenile patient
Milena M Lackovic, Bojan D Joksimovic, Jelena C Babovic, Esma R Isenovic, Zoran M Gluvic
Milena M Lackovic, Bojan D Joksimovic, Zoran M Gluvic, Department of Endocrinology, University Clinical-Hospital Centre Zemun-Belgrade, Faculty of Medicine, University of Belgrade, Belgrade 11080, Serbia
Jelena C Babovic, Department of Geriatrics, University Clinical-Hospital Centre Zemun-Belgrade, Faculty of Medicine, University of Belgrade, Belgrade 11080, Serbia
Esma R Isenovic, Department of Radiobiology and Molecular Genetics, Vinča Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade 11000, Serbia
Co-first authors: Milena M Lackovic and Bojan D Joksimovic.
Co-corresponding authors: Esma R Isenovic and Zoran M Gluvic.
Author contributions: Lackovic MM, Joksimovic BD, and Babovic JC analysed the data and wrote the manuscript; Lackovic MM and Joksimovic BD contributed equally to this article, they are the co-first authors of this manuscript; Isenovic ER and Gluvic ZM designed and edited the manuscript, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Zoran M Gluvic, MD, PhD, Associate Professor, Department of Endocrinology, University Clinical-Hospital Centre Zemun-Belgrade, Faculty of Medicine, University of Belgrade, Vukova 9, Belgrade 11080, Serbia. zorangluvic@yahoo.com
Received: August 16, 2024 Revised: January 13, 2025 Accepted: January 21, 2025 Published online: June 16, 2025 Processing time: 185 Days and 21.8 Hours
Abstract
Acute pancreatitis recurrence should always alert clinicians to primary hyperparathyroidism, especially in younger patients and those with a hereditary condition. When parathyroid abnormalities are adequately recognized and addressed, more recurrent attacks of acute pancreatitis are unlikely to occur.
Core Tip: Primary hyperparathyroidism is a very uncommon cause of acute pancreatitis. Medical management may go unreported due to primary hyperparathyroidism’s gradual progression and, on occasion, normal parathyroid hormone levels despite hypercalcemia. The diagnosis and treatment of juvenile acute pancreatitis, particularly in its recurrent form, require a comprehensive work-up. Clinicians need to be aware that recurrent juvenile pancreatitis may be caused by primary hyperparathyroidism.
