Huang KM, Chen HB, Lin JR. Potential of traditional Chinese medicine lyophilized powder of Poecilobdella manillensis in the treatment of hyperuricemia. World J Clin Cases 2024; 12(36): 6939-6943 [PMID: 39726925 DOI: 10.12998/wjcc.v12.i36.6939]
Corresponding Author of This Article
Hong-Bin Chen, BM BCh, Chief Physician, Department of Gastroenterology, Sanming First Affiliated Hospital of Fujian Medical University, No. 29 Liedong Street, Sanyuan District, Sanming 365000, Fujian Province, China. smchb2008@qq.com
Research Domain of This Article
Microbiology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 26, 2024; 12(36): 6939-6943 Published online Dec 26, 2024. doi: 10.12998/wjcc.v12.i36.6939
Potential of traditional Chinese medicine lyophilized powder of Poecilobdella manillensis in the treatment of hyperuricemia
Kang-Ming Huang, Hong-Bin Chen, Jin-Rong Lin
Kang-Ming Huang, Hong-Bin Chen, Department of Gastroenterology, Sanming First Affiliated Hospital of Fujian Medical University, Sanming 365000, Fujian Province, China
Jin-Rong Lin, Department of Ultrasound imaging, The First Affiliated Hospital of Xiamen University, Xiamen 361000, Fujian Province, China
Author contributions: Huang KM contributed to the discussion and design of the manuscript; Huang KM and Lin JR participated in the writing, editing, and linguistic embellishment of the manuscript; Chen HB designed the overall concept and outlined the manuscript; Huang KM, Lin JR and Chen HB contributed equally to this paper; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Bin Chen, BM BCh, Chief Physician, Department of Gastroenterology, Sanming First Affiliated Hospital of Fujian Medical University, No. 29 Liedong Street, Sanyuan District, Sanming 365000, Fujian Province, China. smchb2008@qq.com
Received: August 3, 2024 Revised: September 23, 2024 Accepted: October 15, 2024 Published online: December 26, 2024 Processing time: 88 Days and 16.8 Hours
Abstract
Traditional Chinese medicine has a long and illustrious history, and with the development of modern science and technology, the research and application of traditional Chinese medicines have continued to progress significantly. Many traditional Chinese medicinal herbs have undergone scientific validation, reinvigorating with new life and vitality, and contributing unique strengths to the advancement of human health. Recently, the discovery that leech total protein extracted from Poecilobdella manillensis lyophilized powder reduces blood uric acid (UA) levels by inhibiting the activity of xanthine oxidase to decrease UA synthesis and promotes UA excretion by regulating different UA transporters in the kidney and intestine has undoubtedly injected new vitality and hope into this field of research. The purpose of this editorial is to comment on this study, explore its strengths and weaknesses, and there is a hope to treat a range of metabolic-related syndromes, including hyperuricemia, by targeting the gut microbiota.
Core Tip: Currently, there are still many limitations in the therapeutic drugs for hyperuricemia (HUA), and the side effects of drugs significantly restrict their clinical application. The total leech total protein (LTP) extracted from the Poecilobdella manillensis lyophilized powder from traditional Chinese medicine can reduce blood uric acid through multiple targets and channels. This paper demonstrates that whole LTP will be an important addition to the treatment of HUA in the future, and is expected to further promote the study of the role of LTP on the regulation of the gut microbiota and the serum metabolome, and provide new insights into the therapeutic strategy of HUA.
