Martínez Nieto M, De Leon Rodríguez ML, Anaya Macias RDC, Lomelí Martínez SM. Periodontitis and chronic kidney disease: A bidirectional relationship based on inflammation and oxidative stress. World J Clin Cases 2024; 12(35): 6775-6781 [DOI: 10.12998/wjcc.v12.i35.6775]
Corresponding Author of This Article
Sarah Monserrat Lomelí Martínez, MSc, PhD, Academic Research, Adjunct Associate Professor, Professor, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, Col. Lindavista, Ocotlán 47810, Mexico. sarah.lomeli@academicos.udg.mx
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Martha Leticia De Leon Rodríguez, Rocio del Carmen Anaya Macias, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlan 47810, Jalisco, Mexico
Sarah Monserrat Lomelí Martínez, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán 47810, Mexico
Sarah Monserrat Lomelí Martínez, Master of Public Health, Department of Well-being and Sustainable Development, Centro Universitario del Norte, Universidad de Guadalajara, Colotlan 46200, Jalisco, Mexico
Author contributions: Martínez Nieto M, Lomelí Martínez SM, De León Rodríguez ML and Anaya Macías RC contributed equally to the preparation of this manuscript; Lomelí Martínez SM and Martínez Nieto M conceptualized the study; Lomelí Martínez SM, Martínez Nieto M, De León Rodríguez ML and Anaya Macías RC performed literature searches; Lomelí Martínez SM, Martínez Nieto M, De León Rodríguez ML wrote the preliminary draft; Martínez Nieto M, Lomelí Martínez SM, De León Rodríguez ML and Anaya Macías RC critically reviewed and approved the manuscript.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sarah Monserrat Lomelí Martínez, MSc, PhD, Academic Research, Adjunct Associate Professor, Professor, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, Col. Lindavista, Ocotlán 47810, Mexico. sarah.lomeli@academicos.udg.mx
Received: July 24, 2024 Revised: August 29, 2024 Accepted: September 9, 2024 Published online: December 16, 2024 Processing time: 91 Days and 20.6 Hours
Abstract
Chronic kidney disease (CKD) and chronic periodontitis (CP) are prevalent conditions which significantly impact public health worldwide. Both diseases share inflammatory and oxidative stress mechanisms, an indication of a likely bidirectional relationship. This editorial explored the association between CKD and CP by highlighting common inflammatory mechanisms and recent research findings that address this interrelationship. Through reviews of recent studies, we discussed how periodontal bacteria may activate systemic immune responses that affect both periodontal and renal tissues. Additionally, meta-analysis data indicated an increased risk of CKD development in patients with CP, and vice versa. The results suggest the need for more rigorous research in the future in order to address the confounding factors and evaluate specific periodontal health interventions and their direct effects on kidney function. We emphasized the importance of comprehensive and multidisciplinary care for the improvement of the overall health of patients affected by CP and CKD.
Core Tip: In this editorial, we reviewed the recent meta-analysis by Yang et al, which investigated the association between chronic periodontitis (CP) and chronic kidney disease (CKD). The analysis showed that CP patients have increased risk of CKD, and vice versa. This review also incorporated findings from other significant studies that support this link. We highlighted the need for more consistent definitions, rigorous adjustment for confounding factors, and well-designed prospective studies to ascertain the causal relationship between CP and CKD. This ongoing investigation is crucial for enhancing the management of periodontal health of CKD patients and for improving overall patient outcomes.
