Miyake K, Hirasawa K, Nishimura H, Tsukahara K. Rare incidence of mucosa-associated lymphoid tissue lymphoma presenting as buccal fat pad tumor: A case report. World J Clin Cases 2024; 12(31): 6506-6512 [PMID: 39507115 DOI: 10.12998/wjcc.v12.i31.6506]
Corresponding Author of This Article
Keitaro Miyake, MD, PhD, Assistant Professor, Department of Otolaryngology, Head and Neck Surgery, Todachuo General Hospital, 1-19-3 Honcho, Toda-shi 335-0023, Saitama, Japan. km0122@tokyo-med.ac.jp
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keitaro Miyake, Kazuhiro Hirasawa, Haruka Nishimura, Department of Otolaryngology, Head and Neck Surgery, Todachuo General Hospital, Toda-shi 335-0023, Saitama, Japan
Kiyoaki Tsukahara, Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University Hospital, Shinjuku-ku 160-0023, Japan
Author contributions: Miyake K designed the study, the main conceptual ideas, and the proof outline; Miyake K, Nishimura H, Hirasawa K, and Tsukahara K collected the data; Miyake K, and Hirasawa K aided in interpreting the results and worked on the manuscript; All authors discussed the results and commented on the manuscript.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this study and accompanying images.
Conflict-of-interest statement: All authors declare that there is no conflict of interest regarding the publication of this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Keitaro Miyake, MD, PhD, Assistant Professor, Department of Otolaryngology, Head and Neck Surgery, Todachuo General Hospital, 1-19-3 Honcho, Toda-shi 335-0023, Saitama, Japan. km0122@tokyo-med.ac.jp
Received: May 29, 2024 Revised: August 13, 2024 Accepted: August 16, 2024 Published online: November 6, 2024 Processing time: 105 Days and 0.4 Hours
Abstract
BACKGROUND
Mucosa-associated lymphoid tissue (MALT) lymphoma, a type of non-Hodgkin lymphoma, originates in the mucosal lining of body organs and internal cavities, including the nose, mouth, lungs, and digestive tract. The lymphoma develops when the body produces abnormal B lymphocytes. These lymphomas develop at the edge of the lymphoid tissue, called the marginal zone, and, hence, are classified as a type of marginal zone lymphomas. They are the most common type of marginal zone lymphomas although their occurrence is rare. To date, no previous cases of MALT lymphoma in the buccal fat pad have been reported.
CASE SUMMARY
We report the case of a patient who presented with a mass on the frontal cheek. Magnetic resonance imaging revealed a tumor in the buccal fat pad, and histopathological and immunohistochemical findings confirmed the diagnosis of MALT lymphoma. The patient had a history of Helicobacter pylori and hepatitis C virus infection, suggesting an association between these infective agents and MALT lymphoma.
CONCLUSION
Consideration of MALT lymphoma is essential in the differential diagnosis of frontal cheek masses.
Core Tip: Mucosa-associated lymphoid tissue (MALT) lymphoma mostly originates from the stomach, although it can originate from other mucosal-lined organs and internal cavities as well. Many cases have suggested a strong association between a history of Helicobacter pylori (H. pylori) infection and the development of gastric MALT lymphoma. In the present study, a patient with a history of H. pylori infection developed a buccal fat pad mass. Upon investigation, it was determined to be a case of extragastric MALT lymphoma. Hence, the role of H. pylori infection in the development of extragastric MALT lymphoma should be considered.
