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Wang XF, Li T, Yang M, Huang Y. Periorbital purpura can be the only initial symptom of primary light chain amyloidosis: A case report. World J Clin Cases 2024; 12(26): 5946-5951 [PMID: 39286381 DOI: 10.12998/wjcc.v12.i26.5946]
World J Clin Cases. Sep 16, 2024; 12(26): 5946-5951 Published online Sep 16, 2024. doi: 10.12998/wjcc.v12.i26.5946
Periorbital purpura can be the only initial symptom of primary light chain amyloidosis: A case report
Xiu-Feng Wang, Ting Li, Man Yang, Yan Huang
Xiu-Feng Wang, Man Yang, Yan Huang, Department of Hematology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan Province, China
Ting Li, Department of Blood Purification, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, Henan Province, China
Co-corresponding authors: Xiu-Feng Wang and Yan Huang.
Author contributions: Wang XF and Huang Y contributed equally to this work as co-corresponding authors; Wang XF contributed to writing; Li T and Yang M contributed to conceptualization and data collection; Huang Y contributed to project administration; All authors have read and approved the final manuscript.
Supported bythe Henan Province Medical Science and Technology Research Plan Joint Construction Project, No. LHGJ20210533; and Xinxiang Science and Technology Research Project, No. GG2020029.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Xiu-Feng Wang, PhD, Doctor, Department of Hematology, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Jiangkang Road, Xinxiang 453100, Henan Province, China. 81848616@qq.com
Received: February 6, 2024 Revised: June 20, 2024 Accepted: June 27, 2024 Published online: September 16, 2024 Processing time: 167 Days and 19.2 Hours
Abstract
BACKGROUND
Primary light chain amyloidosis is a rare and complex disease with complex clinical features and is highly susceptible to misdiagnosis and underdiagnosis in the early stages.
CASE SUMMARY
We report a case of a 47-year-old female patient whose only initial symptom was periorbital purpura, which was not taken seriously enough. As the disease progressed, pleural effusion gradually appeared, and after systematic diagnosis and treatment, she was diagnosed with “primary light chain amyloidosis”. She achieved rapid hematological remission after treatment with a daratumumab + bortezomib + cyclophosphamide + dexamethasone regimen.
CONCLUSION
Periorbital purpura can be the only initial symptom of primary light chain amyloidosis; we should pay attention to the cases where the initial clinical symptoms are only periorbital purpura.
Core Tip: Amyloidosis is a rare and difficult to diagnose disease. Periorbital purpura can be the only initial symptom of primary light chain amyloidosis, and we should pay attention to these cases.
