Risk factors for intensive-care-unit-acquired weakness

Abstract

Wang et al reported 1063 cases from the initial 14 d of intensive care unit (ICU) stay, and analyzed relevant data such as age, comorbidities, recent dosages, vapor pressure dosages, duration of mechanical ventilation, length of ICU stay, and rehabilitation therapy, which are closely related to ICU-acquired weakness (ICU-AW). It is suggested that the length of ICU stay and the duration of mechanical ventilation are the main factors. ICU-AW is the most common neuromuscular injury in the ICU, which affects clinical progression and outcomes of patients. This manuscript helps to improve the early recognition of ICU-AW, thereby reducing mortality and improving prognosis.

Keywords: Risk factors; Intensive care unit; Acquired weakness; Prognosis; Neuromuscular injury

Core Tip: The manuscript is helpful to improve the diagnosis and treatment of intensive-care-unit-acquired weakness (ICU-AW). ICU-AW is the most common neuromuscular injury that affects the clinical progression and outcomes of ICU patients. Multiple mechanisms are involved in the occurrence and development of ICU-AW; however, the relationship between these mechanisms still needs to be elucidated in order to reduce mortality and improve prognosis.