Bai LL, Guo YX, Song SY, Li R, Jiang YQ. Primary large cell neuroendocrine carcinoma of the bladder: A case report. World J Clin Cases 2024; 12(21): 4783-4788 [PMID: 39070845 DOI: 10.12998/wjcc.v12.i21.4783]
Corresponding Author of This Article
Yu-Qing Jiang, PhD, Chief Doctor, Professor, Department of Urology, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Shijiazhuang 050051, Hebei Province, China. 37300391@hebmu.edu.cn
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 26, 2024; 12(21): 4783-4788 Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4783
Primary large cell neuroendocrine carcinoma of the bladder: A case report
Liang-Liang Bai, Yue-Xian Guo, Shi-Yu Song, Ran Li, Yu-Qing Jiang
Liang-Liang Bai, Yue-Xian Guo, Shi-Yu Song, Ran Li, Yu-Qing Jiang, Department of Urology, Hebei Medical University Third Hospital, Shijiazhuang 050051, Hebei Province, China
Author contributions: Bai LL designed the study and wrote the manuscript; Jiang YQ checked and audited the paper; Guo YX was in charge of patient treatment; Song SY and Li R prepared the figures. All authors gave final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Qing Jiang, PhD, Chief Doctor, Professor, Department of Urology, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Shijiazhuang 050051, Hebei Province, China. 37300391@hebmu.edu.cn
Received: April 1, 2024 Revised: May 15, 2024 Accepted: June 4, 2024 Published online: July 26, 2024 Processing time: 90 Days and 20.2 Hours
Abstract
BACKGROUND
Large cell neuroendocrine carcinoma (LCNEC) of the bladder is a rare non-urothelial tumor of the bladder. The treatment of LCNEC of the bladder is different from that of urothelial carcinoma (UC); therefore, early and accurate diagnosis is particularly important. As LCNEC of the bladder is rare and its clinical symptoms and radiographic features are similar to those of urothelial tumors, the clinical diagnosis of the disease remains challenging.
CASE SUMMARY
We report a 72-year-old female patient who presented with gross hematuria for 3 mo. A solitary tumor located in the anterior wall of the bladder was found by cystoscopy. Pathological examination after biopsy suggested UC of the bladder in the absence of immunohistochemical assessment. The patient underwent partial cystectomy and was finally diagnosed with LCNEC (pT2bN0M0) based on the results of postoperative immunohistochemical examination. During the 10-mo follow-up, no signs of tumor recurrence or metastasis were found.
CONCLUSION
Immunohistochemical examination is essential for diagnosing LCNEC of the bladder. Accurate diagnosis and multidisciplinary treatment in the early stage of the disease are crucial for improving the prognosis.
Core Tip: Large cell neuroendocrine carcinoma (LCNEC) of the bladder is a rare non-urothelial tumor of the bladder. As LCNEC is a rare disease and its clinical symptoms and radiographic features mimic those of urothelial tumors, it may be misdiagnosed as urothelial carcinoma. In this article, we report a patient with LCNEC of the bladder, who was not accurately diagnosed due to the absence of immunohistochemical examination before surgery. We summarize the methods for diagnosing and treating LCNEC of the bladder and highlight the importance of early diagnosis and multimodal treatment.
