Influence of a diet meal plan on pepsinogen I and II, gastrin-17, and nutritional status in gastric ulcer patients

doi:10.12998/wjcc.v12.i21.4574

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Jul 26, 2024; 12(21): 4574-4581
Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4574

Influence of a diet meal plan on pepsinogen I and II, gastrin-17, and nutritional status in gastric ulcer patients

Wei-Wei Zhang, Xiao-Fei Wang, Hai-Yan Yu, Ling-Fang Wang

Wei-Wei Zhang, Xiao-Fei Wang, Ling-Fang Wang, Department of Gastroenterology, Lujiang County Hospital of Traditional Chinese Medicine, Hefei 231500, Anhui Province, China

Hai-Yan Yu, Department of Anorectal Surgery, Lujiang County Hospital of Traditional Chinese Medicine, Hefei 231500, Anhui Province, China

Author contributions: Zhang WW designed the research and wrote the first manuscript; Zhang WW, Wang XF, Yu HY and Wang LF contributed to conceiving the research and analyzing data; Zhang WW and Wang LF conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.

Institutional review board statement: This study was approved by the Ethic Committee of Lujiang County Hospital of Traditional Chinese Medicine.

Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Data sharing statement: No additional data are available.

Corresponding author: Ling-Fang Wang, BSc, Nurse, Department of Gastroenterology, Lujiang County Hospital of Traditional Chinese Medicine, No. 350 Zhouyu Avenue, Lujiang County, Hefei 231500, Anhui Province, China. 17333214751@163.com

Received: April 10, 2024
Revised: May 18, 2024
Accepted: June 13, 2024
Published online: July 26, 2024
Processing time: 82 Days and 1.5 Hours

Abstract

BACKGROUND

Gastric ulcers (GUs) have a high risk of clinical morbidity and recurrence, and further exploration is needed for the prevention, diagnosis, and treatment of the disease.

AIM

To investigated the effects of a diet plan on pepsinogen (PG) I, PG II, gastrin-17 (G-17) levels and nutritional status in patients with GUs.

METHODS

A total of 100 patients with GUs treated between May 2022 and May 2023 were enrolled, with 47 patients in the control group receiving routine nursing and 53 patients in the experimental group receiving dietary nursing intervention based on a diet plan. The study compared the two groups in terms of nursing efficacy, adverse events (vomiting, acid reflux, and celialgia), time to symptom improvement (burning sensation, acid reflux, and celialgia), gastric function (PG I, PG II, and G-17 levels), and nutritional status [prealbumin (PA) and albumin (ALB) levels].

RESULTS

The experimental group showed a markedly higher total effective rate of nursing, a significantly lower incidence of adverse events, and a shorter time to symptom improvement than the control group. Additionally, the experimental group’s post-intervention PG I, PG II, and G-17 levels were significantly lower than pre-intervention or control group levels, whereas PA and ALB levels were significantly higher.

CONCLUSION

The diet plan significantly reduced PG I, PG II, and G-17 levels in patients with GUs and significantly improved their nutritional status.

Keywords: Diet plan; Dietary care; Gastric ulcers; Plan on pepsinogen I; Plan on pepsinogen II; Gastrin-17

Core Tip: Gastric ulcers (GUs) have high clinical morbidity and recurrence, posing varying degrees of adverse effects on patients’ gastric function, physical and mental health, and quality of life. Such patients have also been a key focus of nursing interventions. This study included 100 patients with GUs and compared the clinical effects of routine nursing vs dietary nursing intervention based on a diet plan. We found that the dietary nursing intervention significantly improved nursing efficacy in patients with GUs, preventing vomiting, acid reflux, and celialgia; promoting symptom improvement; and helping restore gastric function and nutritional status, thus providing an effective new option for the clinical nursing of patients with GUs.