Xu L, Xu R, Sun J. Anal metastasis in esophageal cancer: A case report. World J Clin Cases 2024; 12(19): 3925-3930 [PMID: 38994288 DOI: 10.12998/wjcc.v12.i19.3925]
Corresponding Author of This Article
Jing Sun, MD, Professor, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. jingsun0826@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 6, 2024; 12(19): 3925-3930 Published online Jul 6, 2024. doi: 10.12998/wjcc.v12.i19.3925
Anal metastasis in esophageal cancer: A case report
Lu Xu, Rui Xu, Jing Sun
Lu Xu, Rui Xu, Jing Sun, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Sun J proposed a case study for discussion; Xu L conducted in-depth exploration and writing of this case study; Xu R was responsible for proofreading and translating the completed article into English.
Supported byNational Natural Science Foundation of China, No. 82072721; and Natural Science Foundation of Jiangsu Province of China, No. BK20201493.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Sun, MD, Professor, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. jingsun0826@126.com
Received: February 13, 2024 Revised: April 12, 2024 Accepted: April 29, 2024 Published online: July 6, 2024 Processing time: 136 Days and 19.5 Hours
Abstract
BACKGROUND
Esophageal cancer is the sixth leading cause of cancer-related death and eighth most common cancer, affecting > 450000 people worldwide. Esophageal squamous cell carcinoma is the most common histological type, whereas esophageal adenoid cystic carcinoma (EACC) is rare. The liver is the most common distant metastatic site in esophageal cancer. Anal metastasis is rare and has not been reported in clinical practice before. Here, we report anal metastases in a patient with EACC after regular chemotherapy and surgical resection.
CASE SUMMARY
A 61-year-old esophageal cancer patient was found to have lung and brain metastases during standardized treatment. The patient’s treatment plan was continuously adjusted according to the latest treatment guidelines. However, the patient subsequently noticed rectal bleeding and itching, and after obtaining pathology results at the local hospital, anal metastasis of esophageal cancer was diagnosed.
CONCLUSION
Postoperative pathology and immunohistochemistry confirmed EACC with rare anal metastasis. More exploration of EACC diagnosis and treatment is needed.
Core Tip: Adenoid cystic carcinoma of the esophagus is easily misdiagnosed by endoscopic pathology. Surgical pathology and immunohistochemistry are the gold standards for diagnosis and at present, surgery is still our preferred treatment option. Adjuvant chemotherapy and targeted therapy are given for patients with distant metastasis. Whilst radiotherapy can be used locally, there has not been a precise study on optimal chemotherapy regimens. More research is needed to explore treatment options for esophageal adenoid cystic carcinoma.
