Iron and ferritin effects on intensive care unit mortality: A meta-analysis

Abstract

BACKGROUND

The effect of serum iron or ferritin parameters on mortality among critically ill patients is not well characterized.

AIM

To determine the association between serum iron or ferritin parameters and mortality among critically ill patients.

METHODS

Web of Science, Embase, PubMed, and Cochrane Library databases were searched for studies on serum iron or ferritin parameters and mortality among critically ill patients. Two reviewers independently assessed, selected, and abstracted data from studies reporting on serum iron or ferritin parameters and mortality among critically ill patients. Data on serum iron or ferritin levels, mortality, and demographics were extracted.

RESULTS

Nineteen studies comprising 125490 patients were eligible for inclusion. We observed a slight negative effect of serum ferritin on mortality in the United States population [relative risk (RR) 1.002; 95%CI: 1.002-1.004). In patients with sepsis, serum iron had a significant negative effect on mortality (RR = 1.567; 95%CI: 1.208-1.925).

CONCLUSION

This systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with sepsis. Furthermore, it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population.

Keywords: Iron; Ferritin; Mortality; Critically ill; Meta analysis

Core Tip: This systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with sepsis. Furthermore, it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population. This guide provides direction for future prognostic assessments in patients with sepsis. Further high-quality cohort studies and experimental studies on molecular mechanisms are needed to confirm our findings.