Ji X, Chen H. Detection and analysis of serum bile acid profile in patients with colonic polyps. World J Clin Cases 2024; 12(13): 2160-2172 [PMID: 38808335 DOI: 10.12998/wjcc.v12.i13.2160]
Corresponding Author of This Article
Hong Chen, Doctor, Professor, Department of Gastroenterology, Zhongda Hospital Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. njchenhong66@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 6, 2024; 12(13): 2160-2172 Published online May 6, 2024. doi: 10.12998/wjcc.v12.i13.2160
Detection and analysis of serum bile acid profile in patients with colonic polyps
Xin Ji, Hong Chen
Xin Ji, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Hong Chen, Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing 210009, Jiangsu Province, China
Author contributions: Ji X and Chen H provided the conception and design of the research; Ji X collected and analyzed the data, wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Zhongda Hospital Institutional Review Board (Approval No.2021ZDSYLL297-P01).
Informed consent statement: This study was a retrospective study that collected existing clinical data from relevant populations through the hospital's electronic case system for statistical analysis. Therefore, we apologize that we are unable to provide informed consent.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Data sharing statement: Data supporting the research article are available from the corresponding author or first author on reasonable request.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Chen, Doctor, Professor, Department of Gastroenterology, Zhongda Hospital Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. njchenhong66@163.com
Received: December 14, 2023 Peer-review started: December 14, 2023 First decision: February 12, 2024 Revised: February 21, 2024 Accepted: March 28, 2024 Article in press: March 28, 2024 Published online: May 6, 2024 Processing time: 133 Days and 0.6 Hours
Abstract
BACKGROUND
Analyzing the variations in serum bile acid (BA) profile can provide a certain biological basis for early warning and prevention of various diseases. There is currently no comprehensive study on the relationship between the serum BA profile and colonic polyps.
AIM
To study the serum BA profile detection results of patients with colonic polyps, and analyze the correlation between BA and colonic polyps.
METHODS
From January 1, 2022, to June 1, 2023, 204 patients with colonic polyps who were diagnosed and treated at Zhongda Hospital Southeast University were chosen as the study subjects, and 135 non-polyp people who underwent physical examination were chosen as the control group. Gathering all patients' clinical information, typical biochemical indicators, and BA profile.
RESULTS
Compared with the control group, the serum levels of taurocholic acid, glycocholic acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid in the colonic polyp group were significantly higher than those in the control group, while the content of deoxycholic acid (DCA) was lower than that in the control group (P < 0.05). When colonic polyps were analyzed as subgroups, it was shown that there was a strong correlation between changes in the BA profile and polyp diameter, location, morphology, pathological kind, etc.
CONCLUSION
The serum BA profile showed significant changes in patients with colonic polyps, with a significant increase in primary conjugated BA content and a decrease in secondary free bile acid DCA content. There is a certain correlation between primary free BA and pathological parameters of polyps.
Core Tip: This study shows that the serum primary conjugated bile acid (BA) levels in the colonic polyp group were significantly higher than those in the control group (P < 0.05), while the secondary free BA, deoxycholic acid content was lower than that in the control group. Patients with various polyp sizes, locations, morphologies, and pathological types had variable serum BA profile, according to subgroup study of colonic polyps. Therefore, analyzing the changes in serum BA profile may provide new ideas for finding new targets for the treatment of colonic tumors.
