Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2023; 11(7): 1607-1614
Published online Mar 6, 2023. doi: 10.12998/wjcc.v11.i7.1607
Mucosa-associated lymphoid tissue lymphoma of the trachea treated with radiotherapy: A case report
Chan-Jun Zhen, Ping Zhang, Wen-Wen Bai, Yu-Zhi Song, Jun-Li Liang, Xue-Ying Qiao, Zhi-Guo Zhou
Chan-Jun Zhen, Ping Zhang, Wen-Wen Bai, Yu-Zhi Song, Xue-Ying Qiao, Zhi-Guo Zhou, Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Jun-Li Liang, Nursing Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Zhen CJ and Zhang P contributed to conceptualization; Bai WW contributed to software; Song YZ contributed to formal analysis; Liang JL contributed to validation; Qiao XY contributed to visualization; Zhou ZG contributed to supervision; All authors have read and approve the final manuscript.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Guo Zhou, PhD, Chief Physician, Director, Doctor, Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. chenk777@126.com
Received: November 11, 2022
Peer-review started: November 11, 2022
First decision: December 26, 2022
Revised: January 4, 2023
Accepted: February 10, 2023
Article in press: February 10, 2023
Published online: March 6, 2023
Processing time: 111 Days and 1.5 Hours
Abstract
BACKGROUND

Mucosa-associated lymphoid tissue (MALT) lymphoma originates in the marginal zone of lymphoid tissue. lung is one of the most frequent non-gastrointestinal organs involved, here known as bronchus-associated lymphoid tissue (BALT) lymphoma. BALT lymphoma of unknown etiology, and most patients are asymptomatic. The treatment of BALT lymphoma is controversial.

CASE SUMMARY

A 55-year-old man admitted to hospital had a three-month history of progressively coughing up yellow sputum, chest stuffiness, and shortness of breath. Fiberoptic bronchoscopy revealed mucosal visible beaded bumps 4 cm from the tracheal carina at 9 o 'clock and 3 o 'clock, the right main bronchus, and the right upper lobe bronchus. Biopsy specimens showed MALT lymphoma. Computed tomography virtual bronchoscopy (CTVB) showed uneven main bronchial wall thickening and multiple nodular protrusion. BALT lymphoma stage IE was diagnosed after a staging examination. We treated the patient with radiotherapy (RT) alone. A total dose of 30.6 Gy/17 f/25 d was given. The patient had no obvious adverse reactions during RT. The CTVB was repeated after RT and showed that the right side of the trachea was slightly thickened. CTVB was repeated 1.5 mo after RT and again showed that the right side of the trachea was slightly thickened. Annual CTVB showed no signs of recurrence. The patient now has no symptoms.

CONCLUSION

BALT lymphoma is an uncommon disease and shows good prognosis. The treatment of BALT lymphoma is controversial. In recent years, less invasive diagnostic and therapeutic approaches have been emerging. RT was effective and safe in our case. The use of CTVB could provide a noninvasive, repeatable, and accurate method in diagnosis and follow-up.

Keywords: Mucosa-associated lymphoid tissue lymphoma; Computed tomography virtual bronchoscopy; Radiotherapy; Prognosis; Case Report

Core Tip: The treatment of bronchus-associated lymphoid tissue (BALT) lymphoma is controversial. A patient with BALT lymphoma received radiotherapy (RT) alone. A total dose of 30.6 Gy/17 f/25 d was given. The patient had no obvious adverse reactions during RT. The computed tomography virtual bronchoscopy (CTVB) was repeated after RT and showed that the right side of the trachea was slightly thickened. CTVB was repeated 1.5 mo after RT and again showed that the right side of the trachea was slightly thickened. Annual CTVB showed no signs of recurrence.