Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2023; 11(7): 1521-1527
Published online Mar 6, 2023. doi: 10.12998/wjcc.v11.i7.1521
Invasive breast carcinoma with osteoclast-like stromal giant cells: A case report
Yi-Jie Wang, Chien-Peng Huang, Zhi-Jie Hong, Guo-Shiou Liao, Jyh-Cherng Yu
Yi-Jie Wang, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Chien-Peng Huang, Department of Pathology, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Zhi-Jie Hong, Division of Traumatology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Guo-Shiou Liao, Jyh-Cherng Yu, Division of General Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Author contributions: Wang YJ, Huang CP, Hong ZJ, Liao GS, and Yu JC designed and performed the research; Wang YJ and Yu JC analyzed the data and wrote the manuscript.
Informed consent statement: Informed written consent was obtained from the patient to publish this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jyh-Cherng Yu, MD, Professor, Division of General Surgery, Tri Service General Hospital, National Defense Medical Center, No. 325 Section 2, Chenggong Road, Neihu District, Taipei 114, Taiwan. doc2010612542@gmail.com
Received: October 22, 2022
Peer-review started: October 22, 2022
First decision: November 22, 2022
Revised: December 6, 2022
Accepted: February 16, 2023
Article in press: February 16, 2023
Published online: March 6, 2023
Processing time: 131 Days and 3.3 Hours
Abstract
BACKGROUND

Invasive breast carcinoma with osteoclast-like stromal giant cells (OGCs) is an extremely rare morphology of breast carcinomas. To the best of our knowledge, the most recent case report describing this rare pathology was published six years ago. The mechanism controlling the development of this unique histological formation is still unknown. Further, the prognosis of patients with OGC involvement is also controversial.

CASE SUMMARY

We report the case of a 48-year-old woman, who presented to the outpatient department with a palpable, growing, painless mass in her left breast for about one year. Sonography and mammography revealed a 26.5 mm × 18.8 mm asymmetric, lobular mass with circumscribed margin and the Breast Imaging Reporting and Data System was category 4C. Sono-guided aspiration biopsy revealed invasive ductal carcinoma. The patient underwent breast conserving surgery and was diagnosed with invasive breast carcinoma with OGCs, grade II, with intermediate grade of ductal carcinoma in situ (ER: 80%, 3+, PR: 80%, 3+, HER-2: negative, Ki 67: 30%). Adjuvant chemotherapy and post-operation radiotherapy were initiated thereafter.

CONCLUSION

As a rare morphology of breast cancer, breast carcinoma with OGC occurs most often in relatively young women, has less lymph node involvement, and its occurrence is not race-dependent.

Keywords: Breast carcinoma; Osteoclast stromal giant cell; Pathology; Histochemical stains; Prognosis; Case report

Core Tip: We present a case of invasive breast carcinoma with Osteoclast-like stromal giant cells (OGC). Complete radiographic images, clinico-pathologic characteristic features, and immunohistochemical stains were reported. Breast carcinomas with OGCs are believed to be mostly luminal A invasive carcinomas of no particular type, prevalent among young women, and having good outcomes. Moreover, there seems to be no relationship between the incidence of the disease and ethnicity. Although only one third of the patients develop axillary lymph node metastases, a sentinel node procedure is recommended for these cases.