Shi JJ, Peng Y, Zhang Y, Zhou L, Pan G. Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report. World J Clin Cases 2023; 11(5): 1152-1157 [PMID: 36874420 DOI: 10.12998/wjcc.v11.i5.1152]
Corresponding Author of This Article
Gang Pan, Doctor, MM, Doctor, Department of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. xjxsh@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 16, 2023; 11(5): 1152-1157 Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1152
Langerhans cell histiocytosis misdiagnosed as thyroid malignancy: A case report
Jing-Jing Shi, You Peng, Yu Zhang, Li Zhou, Gang Pan
Jing-Jing Shi, You Peng, Yu Zhang, Li Zhou, Gang Pan, Department of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China
Author contributions: Zhang Y and Zhou L collected the data; Shi JJ and Peng Y wrote the paper; Pan G revised the paper; all authors have read and approved the final manuscript.
Supported bythe Zhejiang Provincial Public Welfare Research Project, No. LGF22H070008.
Informed consent statement: Consent was obtained from the patient and her family for publication of this report.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest to disclose.
CARE Checklist (2016) statement: The author has read the care list (2016) and prepared and revised the manuscript according to the care list (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Pan, Doctor, MM, Doctor, Department of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. xjxsh@163.com
Received: November 1, 2022 Peer-review started: November 1, 2022 First decision: December 19, 2022 Revised: December 31, 2022 Accepted: January 28, 2023 Article in press: January 28, 2023 Published online: February 16, 2023 Processing time: 101 Days and 16.5 Hours
Abstract
BACKGROUND
The incidence of Langerhans cell histiocytosis (LCH) is low, and involvement of the thyroid is even rarer, which results in high missed diagnosis or misdiagnosis rates.
CASE SUMMARY
We report a young woman with a thyroid nodule. Thyroid malignancy was suggested by fine needle aspiration, but she was eventually diagnosed with multisystem LCH, thus avoiding thyroidectomy.
CONCLUSION
The clinical manifestations of LCH involving the thyroid are atypical, and the diagnosis depends on pathology. Surgery is the main method for treating primary thyroid LCH, while chemotherapy is the main treatment method for multisystem LCH.
Core Tip: The incidence of Langerhans cell histiocytosis (LCH) is low. We report a young woman with a thyroid nodule, and thyroid malignancy was considered by fine needle aspiration. But she was eventually diagnosed with multisystem LCH, avoiding thyroidectomy.
