Angioimmunoblastic T-cell lymphoma induced hemophagocytic lymphohistiocytosis and disseminated intravascular coagulopathy: A case report

doi:10.12998/wjcc.v11.i5.1086

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 11, Issue 5

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5193)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

230

WORD

HTML

2331

Figures (1-2)

651

Tables (1-2)

596

Sum=3839

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

243

Download

1119

Sum=1362

Feb 16, 2023 (publication date) through Feb 23, 2026

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Case Report

World J Clin Cases. Feb 16, 2023; 11(5): 1086-1093
Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1086

Angioimmunoblastic T-cell lymphoma induced hemophagocytic lymphohistiocytosis and disseminated intravascular coagulopathy: A case report

Mei Jiang, Jing-Hua Wan, Yi Tu, Yan Shen, Fan-Cong Kong, Zhang-Lin Zhang

Mei Jiang, Jing-Hua Wan, Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

Yi Tu, Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

Yan Shen, Department of Anesthesia, Medical College of Nanchang University, Nanchang 330006, Jiangxi Province, China

Fan-Cong Kong, Department of Hematology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

Zhang-Lin Zhang, Department of Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China

Author contributions: Jiang M and Wan JH contributed equally to this work; Zhang ZL and Kong FC contributed equally and should share the corresponding authorship; Jiang M, Wan JH, Kong FC, and Zhang ZL wrote the manuscript; Jiang M, Tu Y, Shen Y, and Zhang ZL collected the data and revised the manuscript; all authors have read and approved the final manuscript.

Supported by the National Natural Science Foundation of China, No. 82160692 and No. 82160037.

Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Zhang-Lin Zhang, Doctor, Associate Chief Technician, Transfusion, The First Affiliated Hospital of Nanchang University, No. 17 Yongwai Street, Nanchang 330006, Jiangxi Province, China. ndyfy02270@ncu.edu.cn

Received: September 18, 2022
Peer-review started: September 18, 2022
First decision: November 11, 2022
Revised: November 15, 2022
Accepted: January 28, 2023
Article in press: January 28, 2023
Published online: February 16, 2023
Processing time: 148 Days and 17.8 Hours

Abstract

BACKGROUND

Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma, with heterogenous clinical manifestations and poor prognosis. Here, we report a case of AITL induced hemophagocytic lymphohistiocytosis (HLH) and disseminated intravascular coagulopathy (DIC).

CASE SUMMARY

An 83-year-old man presented with fever and purpura of both lower limbs for one month. Groin lymph node puncture and flow cytometry indicated a diagnosis of AITL. Bone marrow examination and other laboratory related indexes indicated DIC and HLH. The patient rapidly succumbed to gastrointestinal bleeding and septic shock.

CONCLUSION

This is the first reported case of AITL induced HLH and DIC. AITL is more aggressive in older adults. In addition to male gender, mediastinal lymphadenopathy, anaemia, and sustained high level of neutrophil-to-lymphocyte ratio may indicate a greater risk of death. Early diagnosis, early detection of severe complications, and prompt and effective treatment are vital.

Keywords: Angioimmunoblastic T-cell lymphoma; Hemophagocytic lymphohistiocytosis; Disseminated intravascular coagulopathy; Prognostic factors; Case report

Core Tip: Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma, with heterogenous clinical manifestations and poor prognosis. Early diagnosis is particularly important. Herein, we report a patient with AITL induced hemophagocytic lymphohistiocytosis (HLH) and disseminated intravascular coagulopathy (DIC). The patient rapidly succumbed to gastrointestinal bleeding and septic shock. The time between onset and death was about one month. To the best of our knowledge, this is the first case of AITL induced HLH and DIC. AITL is more aggressive in older adults. In addition to male gender, mediastinal lymphadenopathy, anaemia, and sustained high level of neutrophil-to-lymphocyte ratio may indicate a greater risk of death. Early diagnosis, early detection of severe complications, and prompt and effective treatment are vital.