Bae M, Huh U, Lee CW, Kim JW. Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis: A case report. World J Clin Cases 2023; 11(34): 8170-8175 [PMID: 38130778 DOI: 10.12998/wjcc.v11.i34.8170]
Corresponding Author of This Article
Up Huh, MD, PhD, Assistant Professor, Surgeon, Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, 179 Gudeok-Ro, Seo-Gu, Busan 49241, South Korea. tymfoo82@gmail.com
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Surgery
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Case Report
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Dec 6, 2023 (publication date) through Mar 3, 2026
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World Journal of Clinical Cases
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Bae M, Huh U, Lee CW, Kim JW. Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis: A case report. World J Clin Cases 2023; 11(34): 8170-8175 [PMID: 38130778 DOI: 10.12998/wjcc.v11.i34.8170]
World J Clin Cases. Dec 6, 2023; 11(34): 8170-8175 Published online Dec 6, 2023. doi: 10.12998/wjcc.v11.i34.8170
Venous adventitial cystic disease is a very rare disease that can cause deep vein thrombosis: A case report
Miju Bae, Up Huh, Chung Won Lee, Jong Won Kim
Miju Bae, Up Huh, Chung Won Lee, Jong Won Kim, Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, Busan 49241, South Korea
Miju Bae, Up Huh, Chung Won Lee, Jong Won Kim, Biomedical Research Institute, Pusan National University Hospital, Busan 49241, South Korea
Author contributions: Bae M, Huh U, and Lee CW contributed to subject assessment; Bae M, Huh U, Lee CW, and Kim JW contributed to drafting the manuscript and data interpretation; Bae M, Huh U, Lee CW, and Kim JW contributed to study conception, design, and supervision; All authors have read and approved the final manuscript.
Supported bythe Bio&Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT), No. RS-2023-00223764.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this study and any accompanying images. This study was approved by the Pusan National University Hospital Institutional Review Board.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Up Huh, MD, PhD, Assistant Professor, Surgeon, Department of Thoracic and Cardiovascular Surgery, Pusan National University School of Medicine, 179 Gudeok-Ro, Seo-Gu, Busan 49241, South Korea. tymfoo82@gmail.com
Received: August 28, 2023 Peer-review started: August 28, 2023 First decision: October 24, 2023 Revised: October 26, 2023 Accepted: November 28, 2023 Article in press: November 28, 2023 Published online: December 6, 2023 Processing time: 100 Days and 0 Hours
Abstract
BACKGROUND
Venous adventitial cystic disease (VACD) is a rare disease characterized by cysts, filled with a gelatinous mucous substance similar to joint fluid, in the adventitia of blood vessels adjacent to the joints. It is often misdiagnosed as deep vein thrombosis (DVT), femoral varices, venous tumors, or lymphadenopathy.
CASE SUMMARY
A 69-year-old woman visited our hospital with a complaint of swelling in the right lower extremity. The patient was diagnosed with DVT and prescribed apixaban at an outpatient clinic. After 3 wk, the patient was hospitalized again because of sudden swelling in the right lower extremity. We diagnosed VACD and performed surgery for cyst removal as well as patch angioplasty and thrombectomy of the right common femoral vein. The patient received anticoagulants for 6 mo and has been doing well without recurrence for 1 year postoperatively.
CONCLUSION
Recurrent VACD requires complete removal of the connections to the joint cavity to prevent recurrence.
Core Tip: Venous adventitious cystic disease is a rare condition characterized by the occurrence of cysts filled with a gelatinous substance similar to synovial fluid in the outer layer of blood vessels adjacent to joints. It can be misdiagnosed as deep vein thrombosis, femoral varices, venous tumors, or lymphadenopathy. To prevent recurrence, it is important to completely remove the connections to the joint cavity.
