Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 16, 2023; 11(32): 7872-7875
Published online Nov 16, 2023. doi: 10.12998/wjcc.v11.i32.7872
Glucocorticoid reduction induced chorea in pediatric-onset systemic lupus erythematosus: A case report
Yan-Qiu Xu, Miao Wang, Ying Zhang
Yan-Qiu Xu, Miao Wang, Ying Zhang, Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China
Author contributions: Xu YQ contributed to the collection of medical record data and writing the first draft; Wang M and Zhang Y contributed to critically reviewed the paper; all authors actively contributed to the writing and reviewing of the article and approved the final version.
Informed consent statement: This study was conducted with the approval of the ethics committee of Chongqing Hospital of Traditional Chinese Medicine (approval No. 2023-GAKY-KS-XYQ). The patient gave explicit informed consent to report her clinical case.
Conflict-of-interest statement: All authors report no disclosures.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Zhang, Doctor, Staff Physician, Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, No. 6 Panxi Qizhi Road, Jiangbei District, Chongqing 400021, China. zhangying_216@126.com
Received: August 5, 2023
Peer-review started: August 5, 2023
First decision: August 30, 2023
Revised: September 12, 2023
Accepted: November 9, 2023
Article in press: November 9, 2023
Published online: November 16, 2023
Processing time: 102 Days and 19.2 Hours
Abstract
BACKGROUND

Pediatric-onset systemic lupus erythematosus (SLE) is typically more severe than adult-onset SLE, with a higher incidence of nervous system involvement. Chorea is a relatively rare neurological complication reported in 2.4%-7% of SLE patients. In particular, chorea induced by glucocorticoid dose reduction is even rarer. Herein, we report the case of a girl with SLE, who developed chorea during the process of glucocorticoid therapy reduction.

CASE SUMMARY

We describe a 14-year-old girl who was diagnosed with SLE. She was treated with methylprednisolone and rituximab, and her symptoms improved. On the second day after the methylprednisolone dose was reduced according to the treatment guidelines, the patient developed chorea. Her condition improved after adjusting her glucocorticoid regimen.

CONCLUSION

This case is a reminder that extra attention to chorea is required in SLE patients during glucocorticoid dose reduction.

Keywords: Glucocorticoid; Chorea; Pediatric systemic lupus erythematosus; Case report

Core Tip: Chorea can be induced by glucocorticoid dose reduction in patients with pediatric-onset systemic lupus erythematosus (SLE). Patients with SLE should be closely monitored during glucocorticoid reduction.