Comparison of drug concentrations in blood and gastric lavage fluid before and after gastric lavage: A case report

doi:10.12998/wjcc.v11.i31.7680

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World Journal of Clinical Cases

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Case Report

World J Clin Cases. Nov 6, 2023; 11(31): 7680-7683
Published online Nov 6, 2023. doi: 10.12998/wjcc.v11.i31.7680

Comparison of drug concentrations in blood and gastric lavage fluid before and after gastric lavage: A case report

Yue Zhou, Jia-Le Tong, Ai-Hua Peng, Shu-Yun Xu

Yue Zhou, Jia-Le Tong, Ai-Hua Peng, Shu-Yun Xu, Department of Emergency Medicine and West China School of Nursing, Laboratory of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

Yue Zhou, Jia-Le Tong, Ai-Hua Peng, Shu-Yun Xu, Disaster Medical Center, Sichuan University, Chengdu 610041, Sichuan Province, China

Author contributions: Zhou Y contributed to manuscript writing and editing, and data collection; Peng AH and Tong JL contributed to data analysis; Xu SY contributed to conceptualization and supervision; All authors have read and approved the final manuscript.

Supported by Early Diagnosis of Venom-Induced Ventricular Fascia Syndrome Based on High Frequency Ultrasound and Shear Wave Elastography, No. 2021YFS0189.

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Shu-Yun Xu, MD, Doctor, Department of Emergency Medicine and West China School of Nursing, Laboratory of Emergency Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. xshuyun2023@163.com

Received: August 24, 2023
Peer-review started: August 24, 2023
First decision: September 28, 2023
Revised: October 2, 2023
Accepted: October 17, 2023
Article in press: October 17, 2023
Published online: November 6, 2023
Processing time: 73 Days and 21.7 Hours

Abstract

BACKGROUND

Gastric lavage (GL) is one of the most important early therapies to remove unabsorbed toxins from the gastrointestinal tract. However, the details of performing gastric lavage remain to be established. There is controversy in clinical practice regarding individual choice of the timing of GL and its efficiency.

CASE SUMMARY

We report the case of a young woman who presented to the Emergency Department with drug intoxication for four hours. We used the latest toxicological screening techniques to compare drug concentrations in the patient's blood and gastric lavage fluid before and after gastric lavage. The results confirmed that gastric lavage was effective in reducing drug concentrations in the stomach; a small amount of drug remained in the stomach at the end of gastric lavage.

CONCLUSION

Gastric lavage is effective in reducing drug concentrations in the stomach, with a small amount of drug remaining in the stomach at the end of gastric lavage.

Keywords: Gastric lavage; Drug concentrations; Oral poisoning; Case report

Core Tip: Gastric lavage (GL) is one of the most critical early therapies for oral poisoning, but details of the treatment protocol remain to be established. Controversies remain in clinical practice regarding individual choice of the GL timing and its efficiency. We report the case of a young woman who presented to the Emergency Department with a drug intoxication for four hours. We used the latest toxicological screening techniques to compare drug concentrations in the patient's blood and GL fluid before and after GL. The results confirm that GL is effective at reducing drug concentrations in the stomach, and we found that a small amount of drug remained in the stomach when the indication for termination of GL was judged conventionally.