Published online Oct 26, 2023. doi: 10.12998/wjcc.v11.i30.7497
Peer-review started: August 23, 2023
First decision: September 26, 2023
Revised: October 3, 2023
Accepted: October 16, 2023
Article in press: October 16, 2023
Published online: October 26, 2023
Processing time: 63 Days and 2.4 Hours
Protein C deficiency is typically associated with venous thromboembolism; however, arterial thrombosis has been reported in several cases. We report the case of a patient with pulmonary thromboembolism and deep vein thrombosis following acute myocardial infarction with high thrombus burden.
A 40-year-old man was diagnosed with pulmonary thromboembolism and deep vein thrombosis without any provoking factors. The patient was treated with anticoagulants for six months, which were then discontinued. Three months after the discontinuation of anticoagulant therapy, the patient was hospitalized with chest pain and diagnosed with acute myocardial infarction with high thrombus burden. Additional tests revealed protein C deficiency associated with thrombophilia. The patient was treated with anticoagulants combined with dual antiplatelet agents for 1 year after percutaneous coronary intervention, and no recurrent events were reported during a follow-up period of 5 years.
Recurrent thromboembolic events including acute myocardial infarction with thrombus should be considered an alarming sign of thrombophilia.
Core Tip: This case report outlines a 40-year-old male patient who experienced a sequence of thromboembolic events, including pulmonary thromboembolism, deep vein thrombosis, and acute myocardial infarction, all accompanied by significant thrombus burdens.