Shi C, Lu N, Yong YJ, Chu HD, Xia AJ. Parathyroid carcinoma: Three case reports. World J Clin Cases 2023; 11(25): 5934-5940 [PMID: 37727485 DOI: 10.12998/wjcc.v11.i25.5934]
Corresponding Author of This Article
Ai-Jun Xia, MD, Chief Doctor, Department of Ultrasound, Yantaishan Hospital, No. 10087 Kejidadao Road, Yantai 264003, Shandong Province, China. xiaaijun1964@sina.com
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 6, 2023; 11(25): 5934-5940 Published online Sep 6, 2023. doi: 10.12998/wjcc.v11.i25.5934
Parathyroid carcinoma: Three case reports
Ce Shi, Ning Lu, Yan-Jie Yong, Hai-Di Chu, Ai-Jun Xia
Ce Shi, Yan-Jie Yong, Ai-Jun Xia, Department of Ultrasound, Yantaishan Hospital, Yantai 264003, Shandong Province, China
Ning Lu, Department of Pathology, Yantaishan Hospital, Yantai 264003, Shandong Province, China
Hai-Di Chu, Department of Thyroid Surgery, Yantaishan Hospital, Yantai 264003, Shandong Province, China
Author contributions: Shi C and Lu N contributed to manuscript writing and editing, and data collection; Yong YJ contributed to data analysis; Chu HD did the surgical appraisal; Xia AJ contributed to conceptualization and supervision; All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient and her parents for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: April 12, 2023 Peer-review started: April 12, 2023 First decision: July 3, 2023 Revised: July 14, 2023 Accepted: August 1, 2023 Article in press: August 1, 2023 Published online: September 6, 2023 Processing time: 142 Days and 8.8 Hours
Abstract
BACKGROUND
Parathyroid carcinoma (PC) is a rare, slow-growing malignant tumor and a rare cause of primary hyperfunctioning of the parathyroid, with a highly variable clinical course, depending on the aggressiveness of the individual tumor and the degree of hypercalcemia.
CASE SUMMARY
The aim of this report is to summarize the diagnosis and treatment of three cases of PC and to review and conclude aspects regarding the three collected cases with reference to other relevant cases to explore the value of ultrasound in the diagnosis of PC. All three patients had hypercalcemia, consisting of a high serum calcium level and a high level of parathyroid hormone that was > 2-fold (even > 30-fold) of the normal upper limit. The ultrasonographic findings of the parathyroid gland showed that the glands were all > 30 mm, and the internal echo was uneven. All patients underwent surgery. PC in three cases was confirmed by routine histopathology and immunohistochemistry.
CONCLUSION
As clinical signs and laboratory results are nonspecific, it is difficult to diagnose PC preoperatively, so imaging examinations are often needed.
Core tip: Parathyroid carcinoma (PC) is a rare malignant tumor with a highly variable clinical course, depending on the aggressiveness of the individual tumor and the degree of hypercalcemia. As clinical signs and laboratory results are nonspecific, it is difficult to diagnose PC before surgery, so relevant imaging examinations are often needed. The aim of this report is to summarize the diagnosis and treatment of three cases of PC and to review and conclude aspects regarding the three collected cases with reference to other relevant cases to explore the value of ultrasound in the diagnosis of PC.
