Published online Jun 26, 2023. doi: 10.12998/wjcc.v11.i18.4412
Peer-review started: April 5, 2023
First decision: April 20, 2023
Revised: May 7, 2023
Accepted: May 30, 2023
Article in press: May 30, 2023
Published online: June 26, 2023
Processing time: 82 Days and 5.9 Hours
Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare form of pancreatic disease. It is characterized by bullous erythematous skin lesions and arthritis, and both are triggered by pancreatic malfunction. Few cases have been described in the literature thus far. Due to the inconsistency in its clinical pre
A 66-year-old polymorbid male patient presented with several superficial abscesses on both lower legs and painful swelling in the knee. Treatment for septic arthritis and septic skin infection over several weeks failed. His general condition deteriorated gradually and worsened with sudden onset of abdominal pain. A diagnosis of necrotizing pancreatitis was made. He subsequently underwent a laparotomy and drainage of the pancreas. Eventually, our patient improved, and his abdominal complaints, knee pain, and dermal lesions resolved.
PPP syndrome is rare and easily misdiagnosed, as abdominal symptoms may be delayed or absent. Clinicians should consider PPP syndrome if they encounter refractory panniculitis in combination with joint infection.
Core Tip: Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare disease. The combination of joint inflammation and abscess-like skin lesions suggests an infectious cause. However, these symptoms are triggered by pancreatic disease. As abdominal symptoms may be delayed or absent, PPP syndrome may be challenging to diagnose and treat. We present our experience in treating a 66-year-old patient with PPP syndrome. In conclusion, PPP syndrome should be considered in cases of hard-to-treat or atypical joint and tissue infections.