Ye Y, Shi ZL, Ren ZC, Sun YL. Furazolidone-induced pulmonary toxicity in Helicobacter pylori infection: Two case reports. World J Clin Cases 2023; 11(12): 2832-2838 [PMID: 37214582 DOI: 10.12998/wjcc.v11.i12.2832]
Corresponding Author of This Article
Yi-Lan Sun, PhD, Chief Physician, Doctor, Geriatric Medicine Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, No. 158 Shangtang Street, Gongshu District, Hangzhou 310014, Zhejiang Province, China. sunylhz1974@126.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 26, 2023; 11(12): 2832-2838 Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2832
Furazolidone-induced pulmonary toxicity in Helicobacter pylori infection: Two case reports
Yao Ye, Zi-Ling Shi, Zhuo-Chao Ren, Yi-Lan Sun
Yao Ye, Zi-Ling Shi, Zhuo-Chao Ren, Yi-Lan Sun, Geriatric Medicine Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Zi-Ling Shi, Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu 233000, Anhui Province, China
Author contributions: Ye Y, Shi ZL, Ren ZC, and Sun YL conceptualized and designed the study, collected and analyzed data, they have read and approved the final manuscript; Ye Y and Shi ZL contributed to writing-original draft preparation; Ye Y, Ren ZC and Sun YL contributed to writing-review and editing, treatment of the patient; Sun YL contributed to supervision.
Informed consent statement: Written informed consent was obtained from the patients for the publication of this case report.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Lan Sun, PhD, Chief Physician, Doctor, Geriatric Medicine Center, Department of Pulmonary and Critical Care Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, No. 158 Shangtang Street, Gongshu District, Hangzhou 310014, Zhejiang Province, China. sunylhz1974@126.com
Received: December 30, 2022 Peer-review started: December 30, 2022 First decision: February 2, 2023 Revised: February 7, 2023 Accepted: March 30, 2023 Article in press: March 30, 2023 Published online: April 26, 2023 Processing time: 116 Days and 14.7 Hours
Abstract
BACKGROUND
Helicobacter pylori (H. pylori) infection is a global problem, causing significant morbidity and mortality. Furazolidone is recommended to eradicate H. pylori infections in China owing to the highly associated antibiotic resistance.
CASE SUMMARY
This article presents two cases of lung injury caused by furazolidone treatment of H. pylori infection and the relevant literature review. Two patients developed symptoms, including fever, cough, and fatigue after receiving a course of furazolidone for H. pylori infection. Chest computed tomography showed bilateral interstitial infiltrates. Laboratory studies revealed elevated blood eosinophil count. After discontinuing furazolidone with or without the use of corticosteroids, the symptoms improved rapidly. A PubMed database literature search revealed three reported cases of lung injury suggestive of furazolidone-induced pulmonary toxicity.
CONCLUSION
Clinicians should be aware of the side effects associated with the administration of furazolidone to eradicate H. pylori infection.
Core Tip: Furazolidone should be used as a treatment option for Helicobacter pylori (H. pylori) eradication in China because of high antibiotic resistance. We present two cases of furazolidone-induced pulmonary hypersensitivity determined by the Naranjo Adverse Drug Reaction Probability Scale score. Clinicians should be aware of the adverse effects of furazolidone, especially as it is widely used in the treatment of H. pylori infection in China.
