Pancreatic cancer and depression

doi:10.12998/wjcc.v11.i12.2631

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Apr 26, 2023; 11(12): 2631-2636
Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2631

Pancreatic cancer and depression

Kalliopi Michoglou, Amsajini Ravinthiranathan, Saw San Ti, Saoirse Dolly, Kiruthikah Thillai

Kalliopi Michoglou, Amsajini Ravinthiranathan, Saw San Ti, Saoirse Dolly, Kiruthikah Thillai, Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, London Se1 9RT, United Kingdom

Author contributions: All authors contributed equally to the writing of this article; all authors read and approved the final version of this paper.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Kiruthikah Thillai, Doctor, FRCP, MBBS, MD, MRCP, PhD, Doctor, Department of Oncology, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London SE1 9RT, United Kingdom. kiruthikah.thillai@gstt.nhs.uk

Received: November 19, 2022
Peer-review started: November 19, 2022
First decision: December 10, 2022
Revised: February 10, 2023
Accepted: March 27, 2023
Article in press: March 27, 2023
Published online: April 26, 2023
Processing time: 157 Days and 11.2 Hours

Abstract

Pancreatic cancer is a highly devastating disease with high mortality rates. Even patients who undergo potential curative surgery have a high risk for recurrence. The incidence of depression and anxiety are higher in patients with cancer than the general population. However, patients with pancreatic cancer are at most of risk of both depression and anxiety and there seems to be a biological link. In some patients, depression seems to be a precursor to pancreatic cancer. In this article we discuss the biological link between depression anxiety and hepatobiliary malignancies and discuss treatment strategies.

Keywords: Pancreatic cancer; Depression; Anxiety; Cytokines; Gastrointestinal malignancies

Core Tip: Pancreatic cancer has one of the highest mortality rates of all malignancies. There is a strong correlation between pancreatic cancer and depression and we discuss the evidence behind this.