Liver manifestations in COVID-19 patients: A review article

Abstract

The coronavirus disease 2019 (COVID-19) initially presented as a disease that affected the lungs. Then, studies revealed that it intricately affected disparate organs in the human body, with the liver being one of the most affected organs. This review aimed to assess the association between COVID-19 and liver function, shedding light on its clinical implication. However, its exact pathophysiology remains unclear, involving many factors, such as active viral replication in the liver cells, direct cytotoxic effects of the virus on the liver or adverse reactions to viral antigens. Liver symptoms are mild-to-moderate transaminase elevation. In some patients, with underlying liver disease, more serious outcomes are observed. Thus, liver function should be meticulously considered in patients with COVID-19.

Keywords: COVID-19; Liver injury; Liver disease; Liver manifestations

Core Tip: Coronavirus disease or coronavirus disease 2019 (COVID-19) is not only a respiratory illness but it can also affect the gastrointestinal system particularly the liver. Although the exact pathophysiology is unknown, more serious outcomes are seen when there is an underlying liver disease. Meticulous attention should be given to liver function in patients with COVID-19 infection.