Published online Jan 6, 2023. doi: 10.12998/wjcc.v11.i1.201
Peer-review started: October 1, 2022
First decision: October 21, 2022
Revised: November 5, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 6, 2023
Processing time: 95 Days and 11.9 Hours
Extraskeletal Ewing sarcoma (EES) is a rare and highly malignant small round cell tumor associated with a poor clinical outcome. Ewing sarcoma (ES) involving the stomach is an uncommon presentation and can be easily confused with other small round cell tumors. We herein present a rare case of ES involving the gastric area.
We report a case of gastric ES in a 19-year-old female patient who initially presented with a complaint of a tender epigastric mass for 5 d. Contrast-enhanced abdominal computed tomography revealed a soft-tissue-density mass with a diameter of 8.5 cm between the liver and stomach; the mass was connected to the gastric antrum. Then, the mass was surgically excised completely. Upon histopathological, immunophenotype and molecular analysis, the mass was identified to be a primary gastric ES.
EES is an aggressive tumor with poor prognosis. Therefore, early diagnosis and timely intervention are essential for a good prognosis. It is imperative for us to raise awareness about this rare tumor. Surgical resection is still the best treatment option.
Core Tip: Ewing sarcoma (ES) is a rare and highly malignant small round cell tumor. Extraskeletal ES is more common in the paravertebral region, extremities, and retroperitoneum and very rarely occurs in the stomach. Due to its rarity, there are few studies on its clinicopathological characteristics and diagnostic protocols. It is an aggressive tumor with poor prognosis, and therefore, early diagnosis and timely intervention are vital for a good prognosis. Herein, we report on a case of primary gastric ES which was timely resected surgically. This was followed by chemotherapy, which was comprised of alternating vincristine–doxorubicin, cyclophosphamide, and ifosfamide–etoposide every 3 wk. Ultimately, the patient was tumor-free and achieved an excellent prognosis.