Pathological pattern of endometrial abnormalities in postmenopausal women with bleeding or thickened endometrium

doi:10.12998/wjcc.v10.i7.2159

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 7

This Article

Peer-Review Report of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7879)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-3) series.

Item

Count

PDF

310

WORD

146

HTML

4295

Tables (1-3)

719

Sum=5470

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

516

Download

1895

Sum=2411

Mar 6, 2022 (publication date) through Feb 26, 2026

Times Cited of This Article

Times Cited (6)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Observational Study

World J Clin Cases. Mar 6, 2022; 10(7): 2159-2165
Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2159

Pathological pattern of endometrial abnormalities in postmenopausal women with bleeding or thickened endometrium

Hui Xue, Wen-Jing Shen, Yi Zhang

Hui Xue, Wen-Jing Shen, Yi Zhang, Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China

Author contributions: Zhang Y designed the study; Xue H and Shen WJ performed in the data acquisition and analysis, drafted and revised the manuscript; all authors have read and approved the final manuscript to be submitted.

Supported by Key Research and Development Project in Department of Science and Technology, Liaoning Province, No. 2017225025.

Institutional review board statement: This study was reviewed and approved by the Science and Research Office of First Affiliated Hospital of China Medical University (Shenyang, China).

Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: There are no conflicts of interest to report.

Data sharing statement: No additional data are available.

STROBE statement: The authors have read the STROBE Statement—checklist of items and the manuscript was prepared and revised accordingly.

Corresponding author: Yi Zhang, MD, PhD, Chief Doctor, Department of Gynecology, The First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang 110001, Liaoning Province, China. syzi@163.com

Received: August 6, 2021
Peer-review started: August 6, 2021
First decision: September 1, 2021
Revised: September 11, 2021
Accepted: January 17, 2022
Article in press: January 17, 2022
Published online: March 6, 2022
Processing time: 208 Days and 4.2 Hours

Abstract

BACKGROUND

Postmenopausal bleeding and an endometrial thickness ≥ 5 mm on sonograms of menopausal women can indicate the presence of endometrial lesions. Diagnostic hysteroscopy is a powerful method for endometrial diseases.

AIM

To investigate the pathological pattern of endometrial abnormalities in postmenopausal women with bleeding or asymptomatic thickened endometrium diagnosed by hysteroscopy.

METHODS

A total of 187 postmenopausal women with bleeding or asymptomatic thickened endometrium underwent diagnostic hysteroscopy. The women were subsequently divided into three groups: Postmenopausal bleeding (PMB) group (n = 84), asymptomatic group (n = 94), and additional group (n = 9). Women in the additional group manifested abdominal pain and leukorrhagia.

RESULTS

Among the 187 patients examined, 84 (44.9%) were diagnosed with PMB and 94 (50.3%) with asymptomatic thickened endometrium. Endometrial polyp was the most common endometrial abnormality, which was detected in 51.2%, 76.6% and 77.8% of the PMB, asymptomatic, and additional groups, respectively. In the PMB group, 7 (8.3%) women had hyperplasia with atypia and 14 (16.7%) had endometrial adenocarcinoma. Fewer malignant lesions were detected in the asymptomatic group. Endometrial hyperplasia without atypia was found in 8.3% of the PMB group and 7.4% of the asymptomatic group.

CONCLUSION

Endometrial polyp was the most common pathology in the PMB group. Diagnostic hysteroscopy is recommended for women with PMB and asymptomatic thickened endometrium.

Keywords: Endometrium; Polyps; Postmenopause; Hysteroscopy; Adenocarcinoma

Core Tip: Postmenopausal bleeding and thickened endometrium in menopausal women indicate the presence of endometrial lesions. These women should undergo further examination to rule out malignancy. In particular, diagnostic hysteroscopy is recommended based on its lower cost, lower rate of complications, and high accuracy.