Shousha HI, Ramadan A, Lithy R, El-Kassas M. Patterns of liver profile disturbance in patients with COVID-19 . World J Clin Cases 2022; 10(7): 2063-2071 [PMID: 35321162 DOI: 10.12998/wjcc.v10.i7.2063]
Corresponding Author of This Article
Mohamed El-Kassas, MD, Associate Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Helwan, Cairo 11795, Egypt. m_elkassas@hq.helwan.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 6, 2022; 10(7): 2063-2071 Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2063
Patterns of liver profile disturbance in patients with COVID-19
Hend Ibrahim Shousha, Ahmed Ramadan, Rania Lithy, Mohamed El-Kassas
Hend Ibrahim Shousha, Ahmed Ramadan, Rania Lithy, Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo 12556, Egypt
Mohamed El-Kassas, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo 11795, Egypt
Author contributions: All authors equally contributed to this paper with conception and design of the work, literature review, drafting and critical revision, editing, and final approval of the final version of the manuscript.
Conflict-of-interest statement: None of the authors have relevant conflict-of-interest to this work.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohamed El-Kassas, MD, Associate Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Helwan, Cairo 11795, Egypt. m_elkassas@hq.helwan.edu.eg
Received: April 1, 2021 Peer-review started: April 1, 2021 First decision: July 3, 2021 Revised: July 17, 2021 Accepted: February 9, 2022 Article in press: February 9, 2022 Published online: March 6, 2022 Processing time: 334 Days and 10.6 Hours
Abstract
Fever and cough are the most common clinical symptoms of coronavirus disease 2019 (COVID-19), but complications (such as pneumonia, respiratory distress syndrome, and multiorgan failure) can occur in people with additional comorbidities. COVID-19 may be a new cause of liver disease, as liver profile disturbance is one of the most common findings among patients. The molecular mechanism underlying this phenomenon, however, is still unknown. In this paper, we review the most current research on the patterns of change in liver profile among patients with COVID-19, the possible explanation for these findings, and the relation to pre-existing liver disease in these patients.
Core tip: Disturbance in the liver profile caused by coronavirus disease 2019 is not a rare event. However, this disturbance is usually mild and has a hepatocellular rather than a cholestatic pattern. It can affect a large number of patients, especially those with a more serious disease course.
