Published online Feb 6, 2022. doi: 10.12998/wjcc.v10.i4.1333
Peer-review started: August 17, 2021
First decision: November 2, 2021
Revised: November 17, 2021
Accepted: January 22, 2021
Article in press: December 22, 2021
Published online: February 6, 2022
Processing time: 159 Days and 8.6 Hours
Single atrium with single ventricle, or a two-chambered heart, is an extremely rare congenital malformation. Few cases with two-chambered heart surviving to adulthood have been reported.
We reported an adult female patient with a two-chambered heart and situs inversus totalis accompanied by multiple pregnancies and abortions. Magnetic resonance imaging detected a two-chambered heart. B-ultrasound-guided uterine aspiration was performed to absorb 8 g and 10 g of organized villus and decidual tissues, respectively, with a small amount of bleeding. Postoperatively, cyanosis and fatigue-induced shortness of breath were gradually relieved. The patient has currently outlived all similar cases reported so far.
Hemodynamic changes in pregnant women with two-chambered heart impaired cardiac function, responsible for hypoperfusion and miscarriage.
Core tip: The two-chambered heart is characterized by common atrioventricular valves connecting the single atrium and single ventricle. Most patients with two-chambered heart die before or around 20 years of age. Pregnancy in these patients is very rare, and it is unknown how the disease might affect the pregnancy outcome. The current patient with a two-chambered heart has lived longer than all similar cases reported to date, and has remained active. The case reported here was accompanied by eight adverse pregnancies and early abortions. Pregnancy may negatively affect cardiac function in patients with a two-chambered heart, and poor heart function could lead to uterine hypoperfusion and subsequent miscarriage.