Treatment of gastric carcinoma with lymphoid stroma by immunotherapy: A case report

doi:10.12998/wjcc.v10.i25.8962

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World Journal of Clinical Cases

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Case Report

World J Clin Cases. Sep 6, 2022; 10(25): 8962-8967
Published online Sep 6, 2022. doi: 10.12998/wjcc.v10.i25.8962

Treatment of gastric carcinoma with lymphoid stroma by immunotherapy: A case report

Yu-Jie Cui, Yan-Yan Ren, Hong-Zhen Zhang

Yu-Jie Cui, Hong-Zhen Zhang, Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China

Yan-Yan Ren, Department of Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China

Author contributions: Zhang HZ and Cui YJ contributed equally to this work; all authors have read and approved the final manuscript.

Supported by the Key R&D Program of Hebei Province, Health Care and Biomedicine, No. 18277718D (to Cui YJ).

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Hong-Zhen Zhang, PhD, Chief Doctor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, Hebei Province, China. zhidu069009@163.com

Received: January 28, 2022
Peer-review started: January 28, 2022
First decision: April 10, 2022
Revised: April 22, 2022
Accepted: July 29, 2022
Article in press: July 29, 2022
Published online: September 6, 2022
Processing time: 209 Days and 18.1 Hours

Abstract

BACKGROUND

Gastric cancer with lymphoid stroma (GCLS) is a rare type of gastric cancer characterized by abundant lymphocytic infiltration of the stroma. It is an Epstein-Barr virus-associated gastric cancer with a better prognosis than typical gastric cancer but with similar symptoms. GCLS diagnosis is based on pathological, histological and immunohistochemical examination and there are no standardized guidelines for treatment.

CASE SUMMARY

This case report describes a 72-year-old man with a 6-mo history of abdominal pain. Endoscopy revealed ulcerative lesions in the stomach and gastric cancer was suspected. A preoperative endoscopic biopsy indicated undifferentiated carcinoma and postoperative pathological, histological and immunohistochemical analyses of the resected specimen confirmed a final diagnosis of GCLS.

CONCLUSION

The patient showed high programmed cell death-ligand 1 expression and recovered well after immunotherapy.

Keywords: Lymphoid stroma; Gastric cancer; Epstein-Barr virus; Programmed cell death-ligand 1; Immunotherapy; Prognosis; Case report

Core Tip: Gastric cancer with lymphoid stroma (GCLS) is a rare type of gastric cancer characterized by abundant lymphocytic infiltration of the stroma. It is an Epstein-Barr virus-associated gastric cancer with a better prognosis than typical gastric cancer but with similar symptoms. GCLS diagnosis is based on pathological, histological and immunohistochemical examination and there are no standardized guidelines for treatment. We report here on a recent case of GCLS in our hospital. The patient recovered well after immunotherapy.