Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2022; 10(21): 7333-7340
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7333
Correlation of magnetic resonance imaging quantitative parameters and apparent diffusion coefficient value with pathological breast cancer
Zhe Wang, Guan-Ying Ren, Qian Yin, Qian Wang
Zhe Wang, Qian Yin, Qian Wang, Department of Medical Imaging, The No. 2 Hospital of Baoding, Baoding 071051, Hebei Province, China
Guan-Ying Ren, Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding 071000, Hebei Province, China
Author contributions: Wang Z and Ren GY contributed equally to this study, and should be considered as co-first authors; Wang Z and Ren GY design the experiment; Wang Z drafted the manuscript; Wang Z, Ren GY, Yin Q, and Wang Q collected the data; Yin Q and Wang Q analysed and interpreted data; Wang Z and Ren GY revised the manuscript.
Supported by Baoding Science and Technology Support Plan Project, No. 17ZF211.
Institutional review board statement: The study was reviewed and approved by The No. 2 Hospital of Baoding Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflict of interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guan-Ying Ren, MD, Attending Doctor, Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, No. 648 Dongfeng Dong Lu, Baoding 071000, Hebei Province, China. renguanying1982@163.com
Received: April 6, 2022
Peer-review started: April 6, 2022
First decision: May 11, 2022
Revised: May 18, 2022
Accepted: June 26, 2022
Article in press: June 26, 2022
Published online: July 26, 2022
Processing time: 95 Days and 22.6 Hours
Abstract
BACKGROUND

China ranks 120th worldwide for the incidence of breast cancer and 163rd for mortality. Early screening, diagnosis, and timely determination of the optimal treatment plan can help ensure clinical efficacy and prognosis.

AIM

To investigate the relationship between quantitative magnetic resonance imaging parameters, apparent diffusion coefficient value, pathological immunohistochemical status, and patient prognosis.

METHODS

A total of 108 patients with breast cancer (breast cancer group) and 110 patients with benign breast tumors (benign group) confirmed by pathological examination at our Hospital from September 2013 to August 2016 were selected. All patients had undergone preoperative magnetic resonance imaging (MRI) examinations, and the quantitative parameters of MRI and apparent diffusion coefficient (ADC) values for the two groups were compared. The MRI quantitative parameters and ADC values of patients with different estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor-2 expression were statistically analyzed. The relationship between the quantitative parameters of MRI and ADC values and patient recurrence was analyzed using receiver operating curves.

RESULTS

The measured values of the quantitative parameters of MRI- Ktrans, Kep, and Ve in the breast cancer group were higher than those in the benign group; the ADC value in the breast cancer group was lower than that in the benign group, and the difference was statistically significant (P < 0.05). The Ktrans, Ve, and ADC values in patients with ER-positive breast cancer were significantly lower than those in patients with negative ER expression (P < 0.05). After 5 years of follow-up, 22 patients with breast cancer experienced postoperative recurrence. The Kep, Ve, and ADC values of the recurrence group were significantly lower than those of the non-recurrence group, and the difference was statistically significant (P < 0.05).

CONCLUSION

MRI quantitative parameters and ADC are related to the expression of breast cancer-related immunological receptor factors and have certain clinical value in assessing postoperative recurrence in patients.

Keywords: Magnetic resonance; Apparent diffusion coefficient; Breast cancer; Immunohistochemistry; Prognosis

Core Tip: The high sensitivity and repeatability of magnetic resonance imaging make it more widely used in disease screening and treatment. Its advantages in soft tissue resolution and radiation make it more meaningful for lesions that cannot be clarified by clinical and ultrasound techniques in breast examination. Especially, diffusion weighted imaging has more advantages in cell structure and cell membrane integrity.