Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2022; 10(21): 7324-7332
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7324
Effects of alendronate sodium combined with InterTan on osteoporotic femoral intertrochanteric fractures and fracture recurrence
Ke-Meng Wang, Shi-Ping Wei, Xiao-Yan Yin, Qing-Ju Meng, Yu-Ming Kong
Ke-Meng Wang, Qing-Ju Meng, Department of Orthopedics, First Affiliated Hospital of Xingtai Medical College, Xingtai 054001, Hebei Province, China
Shi-Ping Wei, Xiao-Yan Yin, Department of Basic Medicine, Xingtai Medical College, Xingtai 054001, Hebei Province, China
Yu-Ming Kong, Department of Orthopedics, The First Hospital of Xingtai, Xingtai 054001, Hebei Province, China
Author contributions: Wang KM designed this study; Wang KM and Wei SP wrote the manuscript; Wang KM, Wei SP, Yin XY, Meng QJ, and Kong YM were responsible for sorting the data; and all authors have read and approve the final manuscript.
Supported by Special Projects for Social Development Areas.
Institutional review board statement: The study was reviewed and approved by The First Hospital of Xingtai Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ke-Meng Wang, MD, Associate Chief Physician, Department of Orthopedics, First Affiliated Hospital of Xingtai Medical College, No. 376 Shunde Road, Xiangdu District, Xingtai 054001, Hebei Province, China. wangkemeng1979@163.com
Received: March 15, 2022
Peer-review started: March 15, 2022
First decision: April 19, 2022
Revised: April 27, 2022
Accepted: June 27, 2022
Article in press: June 21, 2022
Published online: July 26, 2022
Processing time: 117 Days and 23 Hours
Abstract
BACKGROUND

Osteoporosis is a global disease affecting 6.6% of the total population. Osteoporosis complications include fractures, increased bone fragility, and reduced bone strength. The most commonly affected parts are the vertebral body, hip, and wrist.

AIM

To examine the effect of alendronate sodium combined with InterTan for osteoporotic femoral intertrochanteric fractures on bone and fracture recurrence

METHODS

In total, 126 cases of osteoporotic femoral intertrochanteric fractures were selected and divided into two groups according to the 1:1 principle by the simple random method. They were admitted to the Department of Orthopedics, First Affiliated Hospital of Xingtai Medical College, from January 2018 to September 2020. The control group was treated with InterTan fixation combined with placebo, and the observation group with alendronate sodium based on InterTan fixation. Operation-related indicators, complications, and recurrent fractures were compared between the groups. Changes in bone metabolism markers, t value for hip bone mineral density, and Harris Hip Score were observed.

RESULTS

Operation time, intraoperative blood loss, postoperative ambulation time, and complications were compared between the groups, and no significant difference was found. The fracture healing time was significantly shorter in the observation group than in the control group. β-Collagen-specific sequence (β-CTX) and total aminoterminal propeptide of type I procollagen (T-PINP) in the control group at 3 mo after operation were compared with those before operation, and the difference was not significant. Six months after the operation, the β-CTX level decreased and T-PINP level increased. β-CTX level at 3 and 6 mo in the observation group after operation was lower, and T-PINP level was higher, than that before operation. Compared with the control group, T-PINP level of the observation group was significantly higher and β-CTX level was significantly lower at 3 and 6 mo after operation. The t value of hip bone mineral density was compared in the control group before and 1 mo after operation, and significant difference was not found. Compared with the control group, the t value of hip bone mineral density in the observation group was significantly higher at 1, 3, 6, and 12 mo after operation. Compared with the control group, the Harris score of the observation group was significantly higher at 1, 3, 6, and 12 mo after operation. The recurrence rate of fractures in the observation group within 12 mo was 0.00%, which was significantly lower than 6.35% in the control group.

CONCLUSION

Alendronate sodium combined with InterTan in the treatment of osteoporotic femoral intertrochanteric fractures can increase bone mineral density, improve hip joint function, promote fracture healing, and reduce fracture recurrence.

Keywords: Alendronate sodium; InterTan treatment; Osteoporotic femoral intertrochanteric fractures; Bone mineral density; Hip joint function

Core Tip: The osteoporotic intertrochanteric fracture is one of the most common complications of osteoporosis and requires surgical internal fixation. However, for patients with osteoporotic intertrochanteric fractures, osteoporosis can affect the healing rate of fracture ends, with slow fracture healing and reduced exercise possibly aggravating osteoporosis and thereby leading to a vicious circle. Therefore, the treatment of osteoporosis should be strengthened during the treatment of osteoporotic intertrochanteric fractures. In this study, we observed the effect of alendronate sodium combined with InterTan on osteoporosis and fracture recurrence in the treatment of osteoporotic femoral intertrochanteric fractures and discussed its mechanism.