Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2022; 10(16): 5515-5517
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5515
Electroconvulsive therapy plays an irreplaceable role in treatment of major depressive disorder
Mei-Lin Ma, Lian-Ping He
Mei-Lin Ma, Lian-Ping He, School of Medicine, Taizhou University, Taizhou 318000, Zhejiang Province, China
Author contributions: Ma ML contributed to the conception of the research and wrote the letter; He LP contributed to the revision of the letter; all authors approved the final manuscript for submission.
Supported by the Curriculum Reform Project of Taizhou University in 2021, No. xkg2021087.
Conflict-of-interest statement: The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian-Ping He, PhD, Teacher, School of Medicine, Taizhou University, No. 1139 Shifu Avenue, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. lianpinghe@tzc.edu.cn
Received: February 25, 2022
Peer-review started: February 25, 2022
First decision: April 18, 2022
Revised: April 20, 2022
Accepted: May 5, 2022
Article in press: May 5, 2022
Published online: June 6, 2022
Processing time: 97 Days and 4.9 Hours
Abstract

Major depressive disorder is a serious and common neuropsychiatric disorder that affects more than 350 million people worldwide. Electroconvulsive therapy is the oldest and most effective treatment available for the treatment of severe major depressive disorder. Electroconvulsive therapy modifies structural network changes in patients with major depressive disorder and schizophrenia. And it can also affect neuroinflammatory responses and may have neuroprotective effects. Electroconvulsive therapy plays an irreplaceable role in the treatment of major depressive disorder.

Keywords: Depression; Electroconvulsive therapy; Major depressive disorder; Somatic cell therapy

Core Tip: Electroconvulsive therapy has been shown to be very useful for the acute treatment of major depressive, manic, and mixed states, especially those with a high degree of suicide, as well as catatonic and drug-resistant depression. It should not be seen as a second line of defense after drug therapy.