Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2022; 10(16): 5428-5434
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5428
Ipsilateral synchronous papillary and clear renal cell carcinoma: A case report and review of literature
Jing Yin, Mo Zheng
Jing Yin, Mo Zheng, Department of Pathology, The Fifth Central Hospital of Tianjin, Binhai New Area, Tianjin 300450, China
Author contributions: Yin J was involved in acquisition of the data and drafting and completing the manuscript; Zheng M was involved in the literature review; all authors gave final approval for publication, took full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mo Zheng, MD, Chief Physician, Department of Pathology, The Fifth Central Hospital of Tianjin, No. 41 Zhejiang Road, Tanggu District, Binhai New Area, Tianjin 300450, China. zhengzz1978@126.com
Received: September 19, 2021
Peer-review started: September 19, 2021
First decision: October 25, 2021
Revised: November 12, 2021
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: June 6, 2022
Processing time: 256 Days and 8.6 Hours
Abstract
BACKGROUND

There is limited information on ipsilateral synchronous papillary renal cell carcinoma (PRCC) and clear cell renal cell carcinoma (CCRCC). Therefore, these rare tumors are often misdiagnosed preoperatively as a single tumor with intrarenal metastasis or some other diseases. Effective management and long-term overall survival might be affected because the prognosis of the two tumors differs.

CASE SUMMARY

We describe a case of ipsilateral synchronous PRCC and CCRCC with two histological variants in a 72-year-old man, whose mass was found incidentally, with no other chief complaints and vital signs were normal. Initial ultrasound revealed a hypoechoic lobular mass with a volume of 7.8 cm × 4.8 cm × 2.8 cm in the middle to lower pole of the left kidney. A subsequent contrast-enhanced computed tomography scan showed a single endophytic mass of 7.5 cm in diameter. The patient underwent laparoscopic left radical nephrectomy. A final diagnosis of ipsilateral synchronous PRCC and CCRCC was confirmed by pathological examination. There was no recurrence or metastasis after 25 mo follow-up.

CONCLUSION

We report a case of ipsilateral synchronous PRCC and CCRCC, and review related literature to estimate the prevalence of similar cases. The above descriptions may be expected to help understand the disease, and improve diagnosis in the future.

Keywords: Clear cell renal cell carcinoma; Papillary renal cell carcinoma; Ipsilateral tumor; Synchronous tumor; Kidney; Case report

Core Tip: Ipsilateral synchronous papillary renal cell carcinoma (PRCC) and clear cell renal cell carcinoma (CCRCC) are rare, and reports on this tumor are scarce. We describe an incidentally detected case of this rare disease. Preoperative imaging examinations revealed a single mass on both ultrasound and computed tomography. Further pathological examination confirmed two types of tumors: PRCC and CCRCC. The patient underwent laparoscopic left radical nephrectomy and there was no recurrence or metastasis after 25 mo follow-up.