Wu RC, Gao YH, Sun WW, Zhang XY, Zhang SP. Glomangiomatosis - immunohistochemical study: A case report. World J Clin Cases 2022; 10(16): 5406-5413 [PMID: 35812671 DOI: 10.12998/wjcc.v10.i16.5406]
Corresponding Author of This Article
Shu-Peng Zhang, MD, Doctor, Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Taishan Street, Taishan District, Taian 271000, Shandong Province, China. zhangshp01@163.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ruo-Chen Wu, Ying-Hua Gao, Wen-Wen Sun, Shu-Peng Zhang, Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, Taian 271000, Shandong Province, China
Xiang-Yun Zhang, Department of Pathology, The First People’s Hospital of Jining City, Jining 272000, Shandong Province, China
Author contributions: Zhang SP was the patient’s doctor in charge, was responsible for collecting the medical history, and contributed to the revision of the manuscript; Wu RC was responsible for collecting the medical history, reviewing the literature, drafting the paper, and contributing to the revising of the manuscript; Gao YH, Zhang XY, and Sun WW revised the manuscript; All authors issued final approval for the submitted version.
Supported byAcademic Promotion Program of Shandong First Medical University, No. 2019QL017.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that there is no conflict of interest
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Peng Zhang, MD, Doctor, Department of Pathology, The Second Affiliated Hospital of Shandong First Medical University, No. 706 Taishan Street, Taishan District, Taian 271000, Shandong Province, China. zhangshp01@163.com
Received: September 16, 2021 Peer-review started: September 16, 2021 First decision: December 17, 2021 Revised: February 9, 2022 Accepted: April 2, 2022 Article in press: April 2, 2022 Published online: June 6, 2022 Processing time: 258 Days and 21.4 Hours
Abstract
BACKGROUND
Glomangiomatosis (also known as diffuse glomus tumor) is extremely rare, accounting for only 5% of glomus tumors. The prevalence of glomus tumors is only 2% of soft tissue tumors. Lesions can recur after resection. Although growth may be diffuse or infiltrating and invasive, definitive identifying standards for malignant glomus tumors are lacking. This article describes a case of glomangiomatosis with many nodular masses in the soft tissues of the right foot and calf. A review of the Chinese and English-language literature is included.
CASE SUMMARY
A case of glomangiomatosis in a 55-year-old Chinese woman who presented clinically with many nodular masses in the soft tissues of the right foot and calf. The tumor was examined histologically and immunostaining was performed.
CONCLUSION
Glomangiomatosis occurs most often in young people, in the distal extremities, but is rare. Multiple nodules are even rarer. Only 15 clinicopathological analyses of glomangiomatosis have been reported in the combined Chinese- and English-language literature. In the present case, microscopically, nested vascular globular cells were observed around the blood vessel wall. Immunohistochemistry revealed diffuse immunoreactivity for smooth muscle actin, vimentin, type IV collagen, and Bcl-2. Caldesmon, CD34, and calponin were weakly, partially, and slightly positive, respectively. There was no recurrence 1 year after resection.
Core Tip: We describe a case of glomangiomatosis with many nodular masses in the soft tissues of the right foot and calf, presented by a 55-year-old woman. Pigmented villous nodular synovitis was observed via imaging. Microscopically, nested vascular globular cells around the blood vessel wall were observed. After resection, there was no recurrence during the 1-year follow-up. Although growth may be diffuse or infiltrating and invasive, glomangiomatosis does not meet the identifying standards for malignant glomus tumors.
