Effects of rosuvastatin treatment and other statins on burn wound healing

Table 1 Applied healing topical statin delivery systems

Ref.	System
Salem et al[6], 2022	Silver-capped hydrogel
Aboelazayem et al[13], 2025	Nano sponges
Abu El Hawa et al[21], 2022	Transethosomal gels
Jull et al[22], 2022	Cubosomal nanoparticles
Patel et al[23], 2024	Film-forming sprays
Janipour et al[18], 2023; Heydari et al[24], 2022; Rahamathulla et al[25], 2024	Biological scaffolds (chitosan-based matrices and peptide-loaded hydrogels)
Yu et al[26], 2020; Rezvanian et al[27], 2021	Rosuvastatin with mesenchymal stem cells

Table 2 Efficacy of statins on burn wound healing

Ref.	Subjects	Model	Intervention	Groups	Effects
Ramhormozi et al[91], 2021	60 male Wistar rats	Wistar rats (2nd° burn)	Topical SMV in paraffin	SMV-Veh, RM, RM + SMV, RM-Veh	Activated protein kinase B/mammalian target of rapamycin signaling pathway
Mohajer Ansari et al[84], 2020	48 male Wistar rats	Wistar rats (deep partial burn)	Topical SMV ± BMSCs	Petroleum jelly, BMSCs, SMV	Improved wound closure, epithelial thickness, collagen remodeling
Hosny et al[92], 2020	57 + 15 adult rats (2 stages)	Adult rats	Topical SMV formulations	5-formulation: W/wo SMV, oleic acid, saline, dispersion	Reduced wound diameter, lower interleukin-6 with SMV-coconut oil
Boyko et al[95], 2020	48 burn patients	Burn patients	Oral atorvastatin	Atorvastatin, control	No adverse effects; safe in burns, effective
Akershoek et al[87], 2017	4 female pigs	Pigs (partial/full burn)	Oral atorvastatin/Losartan	No treatment, atorvastatin, losartan	Faster transition to proliferative phase; resolved myofibroblasts
Zhao et al[93], 2013	C57BL/6 male mice (approximately 70–90 total)	C57BL/6 mice (30% TBSA burn)	IP SMV ± inhibitors/KO	Sham, burn + saline, burn + SMV, tumor necrosis factor-α inhibitor/caspase-3, KO ± SMV	Reduced apoptosis via tumor necrosis factor-α/caspase-3 suppression
Beffa et al[94], 2011	48 male CD-1 mice	CD-1 mice (30% TBSA burn)	IP SMV	Placebo, SMV q12h, q24h	Improved survival at 24 hours and 72 hours (P < 0.01)

BMSCs: Bone marrow mesenchymal stromal cells; IP: Intraperitoneal; KO: Knockout; RM: Rapamycin; SMV: Simvastatin; TBSA: Total body surface area; Veh: Vehicle.

Table 3 Efficacy of rosuvastatin on wound healing in recent experimental studies

Ref.	Subjects	Intervention	Groups	Outcome
Santana et al[1], 2025	8 male New Zealand rabbits	Dermal wounds, RSV gel, autologous PRP 32 biopsies	The autologous PRP, RSV, PRP + RSV, control	PRP + RSV has higher collagen I than control
Marneri et al[2], 2024	36 male Wistar rats	Burn trauma, RSV topical	RSV, control (placebo)	RSV higher fibroblast proliferation, angiogenesis, re-epithelization, lower tumor necrosis factor-α, procalcitonin
Zaki et al[5], 2022	30 male Wistar rats	Skin wounds RSV transe-hosomal	Silver sulp-hadiazine RSV-loaded gel control	Nanovesicles enhanced wound healing
Salem et al[6], 2022	30 female Wistar rats	Skin wounds	RSV nano-cubics 16 mg plus RSV 1.4 mg/g hydrogel alone RSV or AgNPs or gentamicin control	Biogel RSV plus AgNPs enhanced wound healing

AgNPs: Silver nanoparticles; PRP: Platelet-rich plasma; RSV: Rosuvastatin.