Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kotoulas SC, Ballas KD, Pavlidis TE. Effects of rosuvastatin treatment and other statins on burn wound healing. World J Methodol 2026; 16(1): 112686 [DOI: 10.5662/wjm.v16.i1.112686]
Corresponding Author of This Article
Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinou Poleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Research Domain of This Article
Surgery
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Methodol. Mar 20, 2026; 16(1): 112686 Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.112686
Effects of rosuvastatin treatment and other statins on burn wound healing
Alexandra G Marneri, Efstathios T Pavlidis, Kalliopi E Stavrati, Christina Mouratidou, Serafeim-Chrysovalantis Kotoulas, Konstantinos D Ballas, Theodoros E Pavlidis
Alexandra G Marneri, Christina Mouratidou, Serafeim-Chrysovalantis Kotoulas, Intensive Care Unit, Hippokration General Hospital, Thessaloniki 54642, Greece
Efstathios T Pavlidis, Kalliopi E Stavrati, Theodoros E Pavlidis, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Konstantinos D Ballas, The Fifth Department of Surgery, Hippokration Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54642, Greece
Co-corresponding authors: Efstathios T Pavlidis and Theodoros E Pavlidis.
Author contributions: Marneri AG, Pavlidis ET, and Stavrati KE designed research and analyzed data; Pavlidis ET and Pavlidis TE have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; Mouratidou C and Kotoulas SC performed research, contributed new analytic tools, evaluated data and review the paper; Βallas KD and Pavlidis TE analyzed data review and approved the paper; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declared no potential conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinou Poleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Received: August 4, 2025 Revised: August 16, 2025 Accepted: September 18, 2025 Published online: March 20, 2026 Processing time: 191 Days and 20.1 Hours
Abstract
Burn injuries represent a significant global public health concern and can result in severe complications. The process of burn wound recovery is intricate, dynamic and involves a series of synchronized events, such as hemostasis, inflammation, proliferation, revascularization, and remodeling. Obstacles in the healing of burn wounds are widespread, both in community and hospital settings. The correlation between the delay in wound-healing of burn injuries with increased mortality rates has led numerous investigators to devise novel therapeutic approaches aimed at accelerating the recovery of burn wounds. Statins, recognized for their varied pleiotropic impacts, have been proposed to enhance wound healing. Insights drawn from studies involving both animals and humans show that statins can speed up wound recovery. Rosuvastatin is one of the most recently studied statins. It promotes wound healing due to its hydrophilic characteristics, in combination with high hepatoselectivity and long half-life, which enable targeted action on the endothelium, improving microcirculation and promoting angiogenesis. Despite the encouraging preliminary results, it has not been widely used, resulting in limited data and heterogeneity. However, further high-quality, evidence-based research is urgently needed to identify whether rosuvastatin may present clinical advantages and improve burn wound recovery through angiogenesis, lymph-angiogenesis and microvascular function. Thus, rosuvastatin could be a potential alternative therapeutic approach for treating burn wounds.
Core Tip: Burn injuries represent a significant global public health concern and can result in severe complications. The correlation between delays in the wound-healing process of burn injuries with increased mortality rates has led numerous investigators to devise novel therapeutic approaches aimed at accelerating the recovery of burn wounds. Statins, in addition to lowering cholesterol, enhance wound healing, particularly in burn wounds. The statins used include lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, and, more recently, Rosuvastatin, a synthetic hydrophilic statin with beneficial efficacy in burns.
