Hagood M, Lucke-Wold B. Long-term neurological consequences of hypertensive disorders of pregnancy: Implications for postpartum monitoring and intervention. World J Methodol 2026; 16(2): 114322 [DOI: 10.5662/wjm.v16.i2.114322]
Corresponding Author of This Article
Brandon Lucke-Wold, MD, PhD, Lillian S Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Road, Gainesville, FL 32608, United States. brandon.lucke-wold@neurosurgery.ufl.edu
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Neurosciences
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Systematic Reviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jun 20, 2026 (publication date) through Apr 23, 2026
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Publication Name
World Journal of Methodology
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2222-0682
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Hagood M, Lucke-Wold B. Long-term neurological consequences of hypertensive disorders of pregnancy: Implications for postpartum monitoring and intervention. World J Methodol 2026; 16(2): 114322 [DOI: 10.5662/wjm.v16.i2.114322]
World J Methodol. Jun 20, 2026; 16(2): 114322 Published online Jun 20, 2026. doi: 10.5662/wjm.v16.i2.114322
Long-term neurological consequences of hypertensive disorders of pregnancy: Implications for postpartum monitoring and intervention
Mackenzie Hagood, Brandon Lucke-Wold
Mackenzie Hagood, Department of Medicine, The University of Toledo College of Medicine, Toledo, OH 43606, United States
Brandon Lucke-Wold, Lillian S Wells Department of Neurosurgery, University of Florida, Gainesville, FL 32608, United States
Author contributions: Hagood M conceived and designed the study, collected and analyzed data, and drafted the manuscript; Lucke-Wold B provided senior supervision, conceptual guidance, critical revision of the manuscript, and overall oversight of the study. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Brandon Lucke-Wold, MD, PhD, Lillian S Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Road, Gainesville, FL 32608, United States. brandon.lucke-wold@neurosurgery.ufl.edu
Received: September 16, 2025 Revised: November 5, 2025 Accepted: February 26, 2026 Published online: June 20, 2026 Processing time: 219 Days and 10.4 Hours
Core Tip
Core Tip: This review of literature examines the neurological consequences for women who have previously experienced gestational hypertension, eclampsia, or preeclampsia. A total of 49 studies were included. After 90 days or greater postpartum, these factors were consistently linked to higher rates of stroke, white matter hyperintensities, structural brain atrophy, and remodeling across studies. The results of this review suggest that pregnancy-related hypertensive disorders may not be isolated obstetrical diseases, but rather long-term risk factors for the development of neurological conditions. Early intervention and surveillance in multidisciplinary treatment, including neurology, vascular medicine, and neurosurgery, may help mitigate negative consequences of disease progression.
