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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2026; 16(1): 110272
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.110272
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.110272
Diagnostic dilemmas in hepatoid adenocarcinoma of the stomach: Navigating clinical and pathological loopholes
Zain Tariq, Affan Faisal, Abdul Basit, Abdullah Iftikhar, Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Abdul M Basil, Department of Medicine, Spinghar Medical University, Kabul 1001, Kābul, Afghanistan
Author contributions: Tariq Z contributed to the study conception and supervision; Faisal A, Basit A, Iftikhar A, and Basil AM contributed to the writing, citation management, and proofreading.
Conflict-of-interest statement: There are no conflicts of interest of any kind among the authors.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abdul M Basil, MD, Department of Medicine, Spinghar Medical University, 4th Alley, Char Rahe Qambar Kabul, Kabul 1001, Kābul, Afghanistan.
Received: June 3, 2025
Revised: July 12, 2025
Accepted: September 10, 2025
Published online: March 20, 2026
Processing time: 252 Days and 15.9 Hours
Revised: July 12, 2025
Accepted: September 10, 2025
Published online: March 20, 2026
Processing time: 252 Days and 15.9 Hours
Core Tip
Core Tip: Hepatoid adenocarcinoma of the stomach is a rare but aggressive tumor that mimics hepatocellular carcinoma both morphologically and serologically. Diagnostic delays occur due to nonspecific symptoms, radiological ambiguities, and variable biomarker profiles. A multidisciplinary and standardized diagnostic approach is critical for improving early detection and clinical outcomes.