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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2026; 16(1): 109733
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.109733
Published online Mar 20, 2026. doi: 10.5662/wjm.v16.i1.109733
Integrating serum ferritin and neutrophil-to-lymphocyte ratio with Sequential Organ Failure Assessment score improves mortality prediction in sepsis
Namra Patel, Vansh Varma, Department of Medicine, GMERS College and Hospital, Valsad 396001, Gujarāt, India
Viral Patel, Department of Internal Medicine, Baptist Hospital of Southeast Texas, Beaumont, TX 77701, United States
Yogesh Murugan, Department of Community Medicine, Shri M P Shah Government Medical College, Jamnagar 361008, India
Kunal Patel, Department of Medicine, GMERS Medical College and Hospital, Valsad 396001, Gujarāt, India
Salim Surani, Department of Medicine and Pharmacology, Texas A&M University, College Station, TX 77843, United States
Author contributions: Patel N and Murugan Y performed the formal analyses; Patel N, Patel V, Murugan Y, Patel K, and Varma V participated in writing the manuscript; Patel N, Patel V, Patel K, Varma V, and Surani S contributed to editing the manuscript; Patel N and Patel V performed the data extraction; Patel N conceptualized and designed the study and developed the methodology; Murugan Y and Surani S contributed to reviewing the manuscript.
Institutional review board statement: This retrospective study uses data from 2008-2022 available in Medical Information Mart for Intensive Care (MIMIC-IV v3.1) from Beth Israel Deaconess Medical Center. Using the deidentified public deidentified database do not require the consent/IRB approval.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: Data are available upon request from the first and corresponding authors.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Salim Surani, MD, Professor, Department of Medicine and Pharma
Received: May 20, 2025
Revised: June 23, 2025
Accepted: September 26, 2025
Published online: March 20, 2026
Processing time: 266 Days and 22 Hours
Revised: June 23, 2025
Accepted: September 26, 2025
Published online: March 20, 2026
Processing time: 266 Days and 22 Hours
Core Tip
Core Tip: This study evaluated the added prognostic value of combining serum ferritin and neutrophil-lymphocyte ratio with Sequential Organ Failure Assessment (SOFA) in predicting 30-day mortality among critically ill adult patients with sepsis. Using data from the Medical Information Mart for Intensive Care database, the integration of these inflammatory biomarkers with SOFA improved model discrimination and reclassification, supporting their potential role in enhancing early risk stratification in sepsis.