Uncovering the role of microbiota and fecal microbiota transplantation in Crohn’s disease: Current advances and future hurdles

doi:10.5662/wjm.v15.i4.106148

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World Journal of Methodology

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2222-0682

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Methodol. Dec 20, 2025; 15(4): 106148
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.106148

Uncovering the role of microbiota and fecal microbiota transplantation in Crohn’s disease: Current advances and future hurdles

Jai P Singh, Maryam Aleissa, Gautham Chitragari, Ernesto Raul Drelichman, Vijay K Mittal, Jasneet Singh Bhullar

Jai P Singh, Maryam Aleissa, Gautham Chitragari, Ernesto Raul Drelichman, Vijay K Mittal, Jasneet Singh Bhullar, Department of Surgery, Henry Ford Providence Hospital, Michigan State University College of Human Medicine, Southfield, MI 48075, United States

Co-corresponding authors: Jai P Singh and Jasneet Singh Bhullar.

Author contributions: Singh J wrote the manuscript; Aleissa M, Chitragari G, Drelichman E, and Mittal V assisted in writing the manuscript; Bhullar J designed research, wrote the paper. Singh J is the primary author, has undertaken the majority of the research work, including designing the paper, reviewing resources, and manuscript preparation.

Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jai P Singh, Department of Surgery, Henry Ford Providence Hospital, Michigan State University College of Human Medicine, Southfield, MI 48075, United States. drjp04@gmail.com

Received: February 18, 2025
Revised: March 26, 2025
Accepted: April 17, 2025
Published online: December 20, 2025
Processing time: 168 Days and 9.9 Hours

Core Tip

Core Tip: This article reviews the role of microbiota in Crohn’s disease (CD) and the effects of fecal microbiota transplantation. CD is a chronic, relapsing condition with a complex pathogenesis involving genetic and environmental factors. The gut microbiota, crucial for various bodily functions, shows dysbiosis in CD, with a reduction in beneficial microbes. This review highlights recent developments in understanding microbiota’s role in CD and its potential in treatment strategies.