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World J Nephrol. Mar 25, 2026; 15(1): 113303
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.113303
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.113303
Clinical profile and outcome of primary membranous nephropathy: A tertiary care center experience from North India
Muzamil Ahmad Wani, Imran Khan, Mohammad Ashraf Bhat, Muzafar Maqsood Wani, Imtiyaz Ahmad Wani, Rayees Yousuf Sheikh, Manzoor Ahmad Parry, Department of Nephrology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar 190011, Jammu and Kashmir, India
Jawad Iqbal Rather, Department of Medicine, Government Medical College, Anantnag 192210, Jammu and Kashmir, India
Author contributions: Wani MA, Khan I, and Rather JI designed the study, collected and analyzed data and wrote the manuscript; Bhat MA, Wani MM, Wani IA, Sheikh RY, and Parry MA helped in conceptualization and critical review of the manuscript. All authors have read and approved the final manuscript.
Institutional review board statement: The study was approved by the Institutional Ethics Committee of Sher-I-Kashmir Institute of Medical Sciences (319/2022).
Informed consent statement: Written informed consent was obtained from all participants prior to enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data can be shared on a reasonable request.
Corresponding author: Jawad Iqbal Rather, DM, MD, Assistant Professor, Department of Medicine, Government Medical College, Dialgam, Anantnag 192210, Jammu and Kashmir, India. jawadiqbal93@gmail.com
Received: August 21, 2025
Revised: September 11, 2025
Accepted: January 6, 2026
Published online: March 25, 2026
Processing time: 205 Days and 11.8 Hours
Revised: September 11, 2025
Accepted: January 6, 2026
Published online: March 25, 2026
Processing time: 205 Days and 11.8 Hours
Core Tip
Core Tip: In this single-center study from Northern India, phospholipase A2 receptor-associated membranous nephropathy was identified as the most common form, with most patients presenting in a high-risk category and a slight female predominance observed. While initial supportive care had limited success, immunosuppressive therapy was highly effective, leading to remission in over 80% of patients. Importantly, there was no significant difference in remission rates between the modified Ponticelli and other immunosuppressive regimens. The study highlights the effectiveness of immunosuppression in this patient population, despite its limitations as a small-scale, single-center observational study.