Elahi T, Ahmed S, Mubarak M. Prognostic value of the MEST-C score in long-term outcomes of immunoglobulin A nephropathy patients: Insights from a developing country. World J Nephrol 2025; 14(4): 112082 [DOI: 10.5527/wjn.v14.i4.112082]
Corresponding Author of This Article
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 25, 2025 (publication date) through Dec 23, 2025
Times Cited of This Article
Times Cited (0)
Journal Information of This Article
Publication Name
World Journal of Nephrology
ISSN
2220-6124
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Elahi T, Ahmed S, Mubarak M. Prognostic value of the MEST-C score in long-term outcomes of immunoglobulin A nephropathy patients: Insights from a developing country. World J Nephrol 2025; 14(4): 112082 [DOI: 10.5527/wjn.v14.i4.112082]
World J Nephrol. Dec 25, 2025; 14(4): 112082 Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.112082
Prognostic value of the MEST-C score in long-term outcomes of immunoglobulin A nephropathy patients: Insights from a developing country
Tabassum Elahi, Saima Ahmed, Muhammed Mubarak
Tabassum Elahi, Saima Ahmed, Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Author contributions: Elahi T and Ahmed S performed the literature search and prepared the initial draft of the manuscript with contributions and feedback from all authors; Mubarak M meticulously revised and refined the manuscript. All authors actively participated in the conceptualization and planning of the study. All authors have reviewed and approved the final version.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Sindh Institute of Urology and Transplantation (approval No. SIUT-ERC-2025/A-551).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The dataset and related documents are available on reasonable request from the first author at elahitabassum@gmail.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Received: July 17, 2025 Revised: August 8, 2025 Accepted: November 4, 2025 Published online: December 25, 2025 Processing time: 159 Days and 14.1 Hours
Core Tip
Core Tip: This study highlights the prognostic significance of the Oxford MEST-C score classification in immunoglobulin A nephropathy patients in Pakistan. Among 118 biopsy-confirmed cases, higher MEST-C scores - particularly E1, T1/2, and C1/C2 lesions - correlated with worse clinical parameters like proteinuria and estimated glomerular filtration rate, and predicted poor kidney survival. Remission rates declined, and end-stage kidney disease rates increased over time, with only 33.3% kidney survival at 10 years. These findings emphasize the value of integrating histopathological scoring with clinical data for early risk stratification. Delayed diagnosis contributed to adverse outcomes, underscoring the need for timely recognition and intervention in immunoglobulin A nephropathy management.
