Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Virol. Mar 25, 2026; 15(1): 117008
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.117008
Published online Mar 25, 2026. doi: 10.5501/wjv.v15.i1.117008
Transplant-free survival in dengue-associated acute liver failure: Current evidence and future directions
Aneel Madhwani, Muhammad Qasim Chaudhry, Wasila Gul Kakar, Syedda Ayesha, Shahab Abid, Department of Medicine, Section of Gastroenterology, Aga Khan University Hospital, Karachi 74800, Sindh, Pakistan
Jamal Ara Rabbani, Department of Medicine, Dow International Medical College, Karachi 74800, Sindh, Pakistan
Co-first authors: Aneel Madhwani and Muhammad Qasim Chaudhry.
Author contributions: Madhwani A contributed in manuscript editing and diagrams; Madhwani A, Chaudhry MQ, Rabbani JA, and Kakar WG contributed in manuscript writing; Madhwani A, Chaudhry MQ, Rabbani JA, and Abid S contributed in manuscript reviewing; Chaudhry MQ, Rabbani JA, and Abid S contributed in manuscript designing, supervising the team and editing; Rabbani JA contributed in designing charts and diagrams of manuscript; Ayesha S and Abid S contributed in reviewing; Madhwani A and Chaudhry MQ contributed equally to this manuscript and are co-first authors. All authors approval the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Shahab Abid, Professor, Department of Medicine, Section of Gastroen
Received: November 26, 2025
Revised: December 29, 2025
Accepted: February 3, 2026
Published online: March 25, 2026
Processing time: 107 Days and 16.1 Hours
Revised: December 29, 2025
Accepted: February 3, 2026
Published online: March 25, 2026
Processing time: 107 Days and 16.1 Hours
Core Tip
Core Tip: Dengue-associated acute liver failure is a severe but potentially reversible condition. With early recognition and prompt supportive management, many patients can achieve transplant-free survival. Understanding the key prognostic indicators and pathophysiological mechanisms is critical for optimizing outcomes, especially in resource-limited, dengue-endemic regions where access to liver transplantation may be restricted.