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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Dec 25, 2025; 14(4): 115626
Published online Dec 25, 2025. doi: 10.5501/wjv.v14.i4.115626
Published online Dec 25, 2025. doi: 10.5501/wjv.v14.i4.115626
Cytomegalovirus reactivation risk after autologous hematopoietic stem cell transplantation: Results of a Tunisian study
Mouna Louiza Ben Moussa, Yasmine Chelbi, Manel Hamdoun, Olfa Bahri, Laboratory of Mic
Mouna Louiza Ben Moussa, Yasmine Chelbi, Rachid Kharrat, Rabeb Berred, Raihane Ben Lakhal, Manel Hamdoun, Olfa Bahri, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis 1007, Tunisia
Rachid Kharrat, Rabeb Berred, Raihane Ben Lakhal, Unit of Clinic Hematology, Aziza Othmana Hospital, Tunis 1008, Tunisia
Author contributions: Ben Moussa ML was responsible for conceptualization, data curation, data collection, formal analysis, and writing original draft; Chelbi Y was responsible for data collection; Kharrat R, Berred R, Ben Lakhal R, and Hamdoun M were responsible for clinical data acquisition and patient management; Bahri O was responsible for supervision, writing review and editing; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: The study protocol was reviewed and approved by the local Ethics Committee of Aziza Othmana Hospital.
Informed consent statement: This study was retrospective in nature and based solely on the review of existing medical records. No direct patient contact or intervention was involved. All data were anonymized before analysis. Therefore, individual informed consent was not required, in accordance with the national and institutional ethical guidelines.
Conflict-of-interest statement: The authors declare no conflict of interest related to this study.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: The datasets generated and analyzed during the present study are not publicly available due to institutional confidentiality policies and the retrospective nature of the data. However, anonymized data may be made available from the corresponding author upon reasonable request and with approval from the local Ethics Committee of Aziza Othmana Hospital.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mouna Louiza Ben Moussa, MD, Laboratory of Microbiology and Biochemistry, Aziza Othmana Hospital, Rue de la Kasbah, Tunis 1008, Tunisia.
Received: October 21, 2025
Revised: November 14, 2025
Accepted: December 8, 2025
Published online: December 25, 2025
Processing time: 65 Days and 12.1 Hours
Revised: November 14, 2025
Accepted: December 8, 2025
Published online: December 25, 2025
Processing time: 65 Days and 12.1 Hours
Core Tip
Core Tip: This retrospective cohort study analyzed cytomegalovirus (CMV) reactivation after autologous hematopoietic stem cell transplantation in 277 patients. CMV reactivation occurred in 6.1% of cases, often spontaneously resolving but occa