Gut microbiome and viral infections: A hidden nexus for immune protection

doi:10.5501/wjv.v14.i3.111912

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (0)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series.

Item

Count

PDF

HTML

Figures (1-2)

Sum=0

Sep 25, 2025 (publication date) through Sep 25, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Virology

ISSN

2220-3249

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Virol. Sep 25, 2025; 14(3): 111912
Published online Sep 25, 2025. doi: 10.5501/wjv.v14.i3.111912

Gut microbiome and viral infections: A hidden nexus for immune protection

Ajay M Gavkare, Neeta L Nanaware, Mahesh N Sonar, Shree V Dhotre, Sachin S Mumbre, Basavraj S Nagoba

Ajay M Gavkare, Department of Physiology, Government Medical College, Buldhana 443001, Maharashtra, India

Neeta L Nanaware, Department of Physiology, Vilasrao Deshmukh Government Medical College, Latur 413512, Maharashtra, India

Mahesh N Sonar, Department of Pediatrics, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India

Shree V Dhotre, Department of Microbiology, Ashwini Rural Medical College, Solapur 413001, Maharashtra, India

Sachin S Mumbre, Department of Community Medicine, Ashwini Rural Medical College, Solapur 413006, India

Basavraj S Nagoba, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Latur 413531, Maharashtra, India

Author contributions: Nagoba BS designed the overall concept and outline of the manuscript; Gavkare AM, and Nanaware NL, Dhotre SV, Sonar MN, Mumbare SS contributed to the discussion and design of the manuscript; Nagoba BS, Gavkare AM contributed to the writing, and editing the manuscript and review of literature; all authors contributed to the finalizing the manuscript.

Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com

Received: July 14, 2025
Revised: August 2, 2025
Accepted: August 27, 2025
Published online: September 25, 2025
Processing time: 75 Days and 3.2 Hours

Core Tip

Core Tip: The gut microbiome and viral infections engage in a bidirectional interplay that governs immune homeostasis by shaping epithelial barrier integrity, cytokine profiles, and Treg/T helper 17 cells balance. Microbiome-targeted interventions—probiotics, prebiotics, fecal microbiota transplantation, dietary modulation, and metabolite-based therapies—hold promise to restore microbial equilibrium, bolster mucosal defenses, and enhance antiviral immunity, though standardization and mechanistic validation are needed to translate these insights into clinical practice.