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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Sep 25, 2025; 14(3): 108405
Published online Sep 25, 2025. doi: 10.5501/wjv.v14.i3.108405
Published online Sep 25, 2025. doi: 10.5501/wjv.v14.i3.108405
Lassa fever: A comprehensive review of virology, clinical management, and global health implications
Praveen Kumar Uppala, Department of Pharmacology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Sita Kumari Karanam, Department of Pharmaceutical Biotechnology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Naga Vishnu Kandra, Department of Phamacology, Santhiram Medical College and General Hospital, Nandyal 518501, Andhra Pradesh, India
Sandhya Edhi, Department of Pharmacognosy, Andhra University College of Pharmaceutical Sciences, Visakhapatnam 530003, Andhra Pradesh, India
Author contributions: Uppala PK was responsible for the design of the study, the conception and acquisition of the data, analysis and interpretation of the data, and drafting the article; Karanam SK was responsible for revising the article critically for important intellectual content and manuscript final review; Kandra NV was responsible for the design and literature search; Edhi S was responsible for the design of the study and acquisition and analysis of the data; All authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflicts of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Praveen Kumar Uppala, PhD, Assistant Professor, Department of Pharmacology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Received: April 14, 2025
Revised: May 4, 2025
Accepted: July 18, 2025
Published online: September 25, 2025
Processing time: 164 Days and 18.3 Hours
Revised: May 4, 2025
Accepted: July 18, 2025
Published online: September 25, 2025
Processing time: 164 Days and 18.3 Hours
Core Tip
Core Tip: This minireview comprehensively examined Lassa fever, a neglected viral hemorrhagic disease endemic to West Africa and emphasized its virology, transmission dynamics, diagnostic challenges, and clinical management. We highlighted recent advances in vaccine development, including DNA-based and viral vector platforms, and called for integrated public health strategies, improved diagnostics, and international collaboration to reduce its growing health burden.