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World J Virol. Jun 25, 2025; 14(2): 103576
Published online Jun 25, 2025. doi: 10.5501/wjv.v14.i2.103576
Marburg virus disease: Emerging threat, pathogenesis, and global public health strategies
Praveen Kumar Uppala, Sita Kumari Karanam, Naga Vishnu Kandra, Sandhya Edhi
Praveen Kumar Uppala, Department of Pharmacology, Maharajah's College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Sita Kumari Karanam, Department of Pharmaceutical Biotechnology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Naga Vishnu Kandra, Department of Pharmacology, Santhiram Medical College and General Hospital, Nandyal 518501, Andhra Pradesh, India
Sandhya Edhi, Andhra University College of Pharmaceutical Sciences, Visakhapatnam 530003, Andhra Pradesh, India
Author contributions: Uppala PK was responsible for design of the study, drafting the article, the conception, acquisition of the data, and analysis interpretation of the data; Karanam SK was responsible for revising it critically for important intellectual content and manuscript final review; Kandra NV was responsible for design and literature search; Edhi S was responsible for concept, design of the study acquisition of the data, and analysis; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Praveen Kumar Uppala, PhD, Assistant Professor, Department of Pharmacology, Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Received: November 25, 2024
Revised: February 26, 2025
Accepted: March 6, 2025
Published online: June 25, 2025
Processing time: 211 Days and 22.7 Hours
Core Tip

Core Tip: Marburg virus disease (MVD) is a highly fatal haemorrhagic fever with no approved vaccines or antiviral treatments. This review highlights the epidemiology, transmission, pathogenesis, and current diagnostic challenges of MVD. Recent advancements in molecular diagnostics, experimental therapeutics, and vaccine candidates such as cAd3-Marburg and Mvabea (MVA-BN-Filo) are discussed, emphasizing the urgent need for clinical validation. Strengthening global surveillance, rapid outbreak response, and international collaboration is critical to mitigating future epidemics. This review underscores the necessity for increased research investment to develop effective prevention and treatment strategies for this deadly virus.